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SML1552

Tipiracil hydrochloride

Name: Tipiracil hydrochloride
Brand: SIGMA

≥98% (HPLC), thymidine phosphorylase inhibitor, powder

Synonym(s):

5-Chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione hydrochloride, TPI hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₉H₁₁ClN₄O₂ · HCl

CAS Number:

183204-72-0

Molecular Weight:

279.12

UNSPSC Code:

12352200

PubChem Substance ID:

329825960

NACRES:

NA.77

MDL number:

MFCD01571384

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated

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Properties

Product Name

Tipiracil hydrochloride, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H₂O: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

[H]Cl.ClC1=C(CN2C(CCC2)=N)NC(NC1=O)=O

InChI

1S/C9H11ClN4O2.ClH/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11;/h11H,1-4H2,(H2,12,13,15,16);1H

InChI key

KGHYQYACJRXCAT-UHFFFAOYSA-N

Gene Information

human ... TYMP(1890)

Description

Biochem/physiol Actions

Tipiracil is an inhibitor of thymidine phosphorylase.

Tipiracil is an inhibitor of thymidine phosphorylase. Tipiracil is used in combination with trifluridine as TAS-102 for the treatment of refractory metastatic colorectal cancer. Tipiracil increases the bioavailability of trifluridine by blocking the enzyme that would otherwise protect the tumors by metabolizing trifluridine.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c