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AB5818-50UL Anti-Potassium Channel Kir4.1 Antibody

This Anti-Potassium Channel Kir4.1 Antibody is validated for use in WB for the detection of Potassium Channel Kir4.1.

Anti-Potassium Channel Kir4.1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Ion Channels & Transporters Gene Symbol: KCNJ10, KIR1.2, Kir4.1, KCNJ13-PEN, Kir1.2, KIR4.1, BIRK-10 UniProt Number: P78508
AB5818-50UL
50 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB5818-50UL
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Potassium Channel Kir4.1 Antibody
      References
      Product Information
      FormatAffinity Purified
      Control
      • Included free of charge with the antibody is 40 μg of control antigen (lyophilized powder). The stock solution of the antigen can be made up using 100 μL of sterile distilled water. For negative control, preincubate 1 μg of protein with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
      PresentationAffinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, 5% sucrose as a stabilizer and 0.025% sodium azide as a preservative. Reconstitute with 50 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for
      Quality SegmentMQ100
      Applications
      ApplicationThis Anti-Potassium Channel Kir4.1 Antibody is validated for use in WB for the detection of Potassium Channel Kir4.1.
      Key Applications
      • Western Blotting
      Application NotesWestern blot: 1:200-1:600 using ECL on rat brain membranes or human platelets.

      Dilutions should be made using a carrier protein such as BSA (1-3%)

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenCONTROL ANTIGEN: Included free of charge with the antibody is 20 μg of control antigen (lyophilized powder). The stock solution of the antigen can be made up using 100 μL of sterile distilled water. For negative control, preincubate 1 μg of protein with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user. Synthetic peptide corresponding to amino acids 356-375 of rat, mouse or human Kir4.1 (Accession P49655).
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes Kir4.1. The epitope does not share homology with any other known proteins.

      SPECIES REACTIVITIES: The antibody is also expected to work with mouse and human due to sequence homology. Other species have not been tested.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes.
      Gene Symbol
      • KCNJ10
      • KIR1.2
      • Kir4.1
      • KCNJ13-PEN
      • Kir1.2
      • KIR4.1
      • BIRK-10
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P78508 # May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity).
      SIZE: 379 amino acids; 42508 Da
      SUBUNIT: Seems to form heterodimer with Kir5.1/KCNJ16. Interacts with INADL (By similarity).
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      SIMILARITY: SwissProt: P78508 ## Belongs to the inward rectifier-type potassium channel family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain lyophilized material at -20°C for up to 12 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Catalogue Number GTIN
      AB5818-50UL 04053252473173

      Documentation

      Anti-Potassium Channel Kir4.1 Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Potassium Channel Kir4.1 Antibody Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-Kir4.1 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2122408 2122408
      RABBIT ANTI-Kir4.1 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2383053 2383053
      RABBIT ANTI-Kir4.1 - 3192036 3192036
      RABBIT ANTI-Kir4.1 - 3301934 3301934
      RABBIT ANTI-Kir4.1 - 3425704 3425704
      RABBIT ANTI-Kir4.1 -2764913 2764913
      RABBIT ANTI-Kir4.1 -2781726 2781726
      RABBIT ANTI-Kir4.1 AFFINITY PURIFIED 2474853
      RABBIT ANTI-Kir4.1 AFFINITY PURIFIED - 3466659 3466659
      RABBIT ANTI-Kir4.1 AFFINITY PURIFIED POLYCLONAL ANTIBODY 3005363
      Show more

      Data Sheet

      Title
      RABBIT ANTI-Kir4.1 AFFINITY PURIFIED POLYCLONAL ANTIBODY

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies