04-046
Anti-SUZ12 Antibody, clone 3C1.2
clone 3C1.2, Upstate®, from mouse
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
3C1.2, monoclonal
Application:
WB
Species reactivity:
human
Citations:
22
Technique(s):
western blot: suitable
Uniprot accession no.:
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
3C1.2, monoclonal
species reactivity
human
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SUZ12(23512)
Application
Research Sub Category
Chromatin Biology
Chromatin Biology
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Anti-SUZ12 Antibody, clone 3C1.2 is a high quality Mouse Monoclonal Antibody for the detection of SUZ12 & has been validated in WB.
Biochem/physiol Actions
SUZ12
Analysis Note
Control
HeLa cell lysate
HeLa cell lysate
Routinely evaluated by immunoblot.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
95 kDa
SUZ12 is a polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Component of the PRC2 complex, which methylates ′Lys-9′ and ′Lys-27′ residues of histone H3.
Immunogen
Full length, recombinant human SUZ12.
Physical form
100 μg of Protein A purified mouse monoclonal IgG1κ in 100 μL of 1X PBS, pH 7, 0.1% Azide.
Format: Purified
Protein A purified
Preparation Note
2 years at -20°C from date of shipment.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Tong Ihn Lee et al.
Cell, 125(2), 301-313 (2006-04-25)
Polycomb group proteins are essential for early development in metazoans, but their contributions to human development are not well understood. We have mapped the Polycomb Repressive Complex 2 (PRC2) subunit SUZ12 across the entire nonrepeat portion of the genome in
H Kehrer-Sawatzki et al.
American journal of human genetics, 75(3), 410-423 (2004-07-17)
Detailed analyses of 20 patients with sporadic neurofibromatosis type 1 (NF1) microdeletions revealed an unexpected high frequency of somatic mosaicism (8/20 [40%]). This proportion of mosaic deletions is much higher than previously anticipated. Of these deletions, 16 were identified by
Marisa R Nucci et al.
The American journal of surgical pathology, 31(1), 65-70 (2007-01-02)
Nonrandom cytogenetic abnormalities of chromosomes 6, 7, and 17 have been reported within low-grade endometrial stromal sarcomas (LGESSs), and among these abnormalities, the t(7;17)(p15;q21) is the most common aberration described. Previously we had shown that this translocation joins 2 genes
Jae Hyun Lee et al.
Human molecular genetics, 18(14), 2567-2574 (2009-04-22)
We recently described two opposing states of transcriptional competency. One is termed 'competent' whereby a gene is capable of responding to trans-acting transcription factors of the cell, such that it is active if appropriate transcriptional activators are present, though it
A proteasome inhibitor-stimulated Nrf1 protein-dependent compensatory increase in proteasome subunit gene expression reduces polycomb group protein level.
Balasubramanian, S; Kanade, S; Han, B; Eckert, RL
The Journal of Biological Chemistry null
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 04-046 | 04053252274077 |
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