Skip to Content
Merck

Key Documents

View All Documentation

8.22288

Periodic acid

for synthesis

Synonym(s):

Periodic acid

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):
H5IO6
CAS Number:
10450-60-9
Molecular Weight:
227.94
UNSPSC Code:
12352301
EC Index Number:
233-937-0
NACRES:
NA.22
MDL number:
MFCD00011344
Assay:
≥98% (iodometric)
Form:
solid
Grade:
synthesis grade
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

grade

synthesis grade

Quality Segment

200

assay

≥98% (iodometric)

form

solid

reaction suitability

reagent type: oxidant

pH

1.2 (20 °C, 100 g/L in H2O)

mp

122 °C

solubility

ethanol: soluble at 20 °C, water: soluble at 20 °C

bulk density

1400 kg/m3

storage temp.

15-25°C

SMILES string

[I](=O)(O)(O)(O)(O)O

InChI

1S/H5IO6/c2-1(3,4,5,6)7/h(H5,2,3,4,5,6,7)

InChI key

TWLXDPFBEPBAQB-UHFFFAOYSA-N

Application

Periodic acid can be used as a reagent for the oxidative cleavage of 1,2 diols to ketones or aldehydes, and epoxides to aldehydes. It is also used in the oxidative cleavage of various protecting groups such as acetonide, tetrahydropyranyl ether (THP), ethoxyethyl acetals, cyclic acetals, dithioacetals, and oxathioacetals.
It can also be used:
  • In the selective N-nitrosation of secondary amines in the presence of sodium nitrite, and wet silica gel.
  • As a stoichiometric oxidant with chromium (IV) acetate for the oxidation of tertiary C−H bonds to tertiary alcohols.
  • In combination with chromium oxide to oxidize primary alcohols to carboxylic acids; alkylbenzenes to benzoic acids; and cyclic benzyl ethers to the corresponding lactones.
  • In the iodination of bulky polyalkyl benzenes in the presence of iodine.
  • In the oxidative coupling of polycyclic aromatic hydrocarbons in the presence of aqueous acetic acid.
  • In the selective oxidation of sulfides to sulfoxides using FeCl3 as a catalyst.

Analysis Note

Assay (iodometric): ≥ 98.0 %
Melting range (lower value): ≥ 124 °C
Melting range (upper value): ≤ 129 °C

Still not finding the right product?

Explore all of our products under Periodic acid

signalword

Danger

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Ox. Sol. 1 - Skin Corr. 1B - STOT RE 1 Oral

target_organs

Thyroid

Storage Class

5.1A - Strongly oxidizing hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library