248924
7-Amino-4-(trifluoromethyl)coumarin
≥99%
Synonym(s):
Coumarin 151
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About This Item
Empirical Formula (Hill Notation):
C10H6F3NO2
CAS Number:
Molecular Weight:
229.16
UNSPSC Code:
12171500
NACRES:
NA.47
PubChem Substance ID:
EC Number:
258-599-1
Beilstein/REAXYS Number:
4456797
MDL number:
Quality Level
assay
≥99%
form
(Powder or Crystals or Chunks)
technique(s)
titration: suitable
mp
221-222 °C (lit.)
λmax
≤207 nm
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp.
room temp
SMILES string
Nc1ccc2c(OC(=O)C=C2C(F)(F)F)c1
InChI
1S/C10H6F3NO2/c11-10(12,13)7-4-9(15)16-8-3-5(14)1-2-6(7)8/h1-4H,14H2
InChI key
JBNOVHJXQSHGRL-UHFFFAOYSA-N
General description
7-Amino-4-(trifluoromethyl)coumarin (AFC) is a novel fluorescent marker used for the detection of proteinases.
Application
Suitable as laser dye
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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S W Cox et al.
Journal of periodontal research, 25(3), 164-171 (1990-05-01)
Substrate impregnated paper discs were prepared using peptidyl derivatives of 7-amino-4-trifluoromethylcoumarin (AFC). After incubation with test solutions, the green, UV-induced fluorescence of AFC liberated by enzyme activity was distinguishable from the blue-violet fluorescence of the substrates. The AFC could then
Mohammad Javad Chaichi et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 59(6), 1145-1150 (2003-03-28)
The chemiluminescence characteristics of seven different cumarin derivatives were studied in detail. The fluorescence and chemiluminescence spectra were compared; all cumarins used were found to act as blue fluorescers. The intensity and kinetic parameters for the chemiluminescent systems were evaluated
E D Pederson et al.
Journal of clinical periodontology, 21(8), 519-525 (1994-09-01)
Treponema denticola (Td) and Porphyromonas gingivalis (Pg) are associated with human moderate and severe adult periodontal diseases. This study quantifies these two anaerobes and their trypsin-like (TL) activities in subgingival plaque collected from both clinically healthy and periodontally diseased sites