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Merck

557525

Ro-32-0432

A selective cell-permeable protein kinase C inhibitor.

Synonym(s):

Ro-32-0432, 2-{8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl}-3-(1-methyl-1H-indol-3-yl)maleimide, HCl, Bisindolylmaleimide XI, HCl, 3-(8-((dimethylamino)methyl)-6,7,8,9-tetrahydropyrido[1,2- a]indol-10-y1)-4-(1-methyl-1 H-indol-3

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About This Item

Empirical Formula (Hill Notation):
C28H28N4O2 · xHCl
CAS Number:
145333-02-4
Molecular Weight:
452.55 (free base basis)
MDL number:
MFCD01319127
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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SMILES string

Cl.[n]21c3c(cc2CC(CC1)CN(C)C)ccc(c3)C4=C(C(=O)NC4=O)c5c6c([n](c5)C)cccc6

InChI

1S/C28H28N4O2.ClH/c1-30(2)15-17-10-11-32-20(12-17)13-18-8-9-19(14-24(18)32)25-26(28(34)29-27(25)33)22-16-31(3)23-7-5-4-6-21(22)23;/h4-9,13-14,16-17H,10-12,15H2,1-3H3,(H,29,33,34);1H

InChI key

WMVQGKBSNAIMHI-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

red

solubility

DMSO: 5 mg/mL

shipped in

ambient

Quality Level

100

Related Categories

General description

A selective cell-permeable protein kinase C inhibitor. Displays about 10-fold greater selectivity for PKCα (IC50 = 9 nM) and 4-fold greater selectivity for PKCβI (IC50 = 28 nM) over PKCε (IC50 = 108 nM). Also prevents T cell-driven chronic inflammatory responses in vivo.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
PKCα
Product does not compete with ATP.
Reversible: no
Target IC50: 9 nM, 28 nM, 108 nM, against PKCα, PKCβI, and PKCε, respectively

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

Other Notes

Birchall, A.M., et al. 1994. J. Pharmacol. Exp. Ther.268, 922.
Wilkinson, S.E., et al. 1993. Biochem. J.294, 335.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Katryna Pampuscenko et al.
Journal of neurochemistry, 154(3), 316-329 (2019-12-14)
Tau is a microtubule-associated protein, found at high levels in neurons, and its aggregation is associated with neurodegeneration. Recently, it was found that tau can be actively secreted from neurons, but the effects of extracellular tau on neuronal viability are unclear.

Global Trade Item Number

SKUGTIN
557525-1MGCN04055977193008

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