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8.52097

Fmoc-Lys(biotin)-OH

Name: Fmoc-Lys(biotin)-OH
Brand: MM

≥95% (TLC), for peptide synthesis, Novabiochem^®

Synonym(s):

Fmoc-Lys(biotin)-OH, N-α-Fmoc-N-ε-biotinyl-L-lysine

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About This Item

Empirical Formula (Hill Notation):

C₃₁H₃₈N₄O₆S

CAS Number:

146987-10-2

Molecular Weight:

594.72

UNSPSC Code:

12352209

NACRES:

NA.22

MDL number:

MFCD00270741

eCl@ss:

34058011

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Properties

Product Name

Fmoc-Lys(biotin)-OH, Novabiochem^®

Quality Segment

200

product line

Novabiochem^®

assay

≥85.0% (HPLC), ≥95% (TLC)

form

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem^®

application(s)

peptide synthesis

functional group

biotin

storage temp.

2-30°C

SMILES string

S1[C@H]([C@H]5NC(=O)N[C@H]5C1)CCCCC(=O)NCCCC[C@H](NC(=O)OCC2c3c(cccc3)c4c2cccc4)C(=O)O

InChI

1S/C31H38N4O6S/c36-27(15-6-5-14-26-28-25(18-42-26)33-30(39)35-28)32-16-8-7-13-24(29(37)38)34-31(40)41-17-23-21-11-3-1-9-19(21)20-10-2-4-12-22(20)23/h1-4,9-12,23-26,28H,5-8,13-18H2,(H,32,36)(H,34,40)(H,37,38)(H2,33,35,39)/t24-,25-,26-,28-/m0/s1

InChI key

OFIBQNGDYNGUEZ-OBXRUURASA-N

Description

General description

A modified lysine derivative for the preparation of biotin-labeled peptides by Fmoc SPPS.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Biotinylation Reagents for Peptide Synthesis

Application

Supplemental Information for: Describes the reaction of amino functionalized resin with HCTU-activated Fmoc-Lys(biotin)-OH in DMF to install a biocytin molecule. Fmoc was deprotected by 20% (K Sapkota, JK Lucas, JW Faulkner, MF Lichte, YL Guo, tandf.figshare.com).

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(CMA2)): ≥ 95 %
Assay (HPLC, area%): ≥ 85.0 % (a/a)
Solubility (0,1 mmole in 1 ml NMP): clearly soluble
Water (K. F.): ≤ 3.0 %
This product can contain up to 10% DMF in order to assure an ideal solubility.

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Other Notes

Replaces: 04-12-1237

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c