77626
N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide
derivatization grade (GC derivatization), LiChropur™, ≥98.0% (GC)
Synonym(s):
MTBSTFA
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About This Item
Linear Formula:
CF3CON(CH3)Si(CH3)2C(CH3)3
CAS Number:
Molecular Weight:
241.33
NACRES:
NA.22
UNSPSC Code:
12352111
Beilstein/REAXYS Number:
3606546
MDL number:
grade
derivatization grade (GC derivatization)
Quality Segment
assay
≥98.0% (GC)
form
liquid
quality
LiChropur™
reaction suitability
reagent type: derivatization reagent
reaction type: Silylations
technique(s)
gas chromatography (GC): suitable
refractive index
n20/D 1.402 (lit.)
bp
172-175 °C (lit.)
density
1.036 g/mL at 25 °C (lit.)
storage temp.
2-8°C
SMILES string
CN(C(=O)C(F)(F)F)[Si](C)(C)C(C)(C)C
InChI
1S/C9H18F3NOSi/c1-8(2,3)15(5,6)13(4)7(14)9(10,11)12/h1-6H3
InChI key
QRKUHYFDBWGLHJ-UHFFFAOYSA-N
General description
N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide is a silylating reagent which replaces the active hydrogen with tert-Butyldimethylsilyl group. The tert-Butyldimethylsilyl derivatives are found to be more resistant to hydrolysis and stable compared to trimethylsilyl (TMS) derivatives. This reagent is suitable for GC-MS analysis since it produces mass spectra, which can be easily interpreted. It is widely used for the silylation of different alcohols, thiols, phenols, carboxylic acids, amines, and amides.
Application
N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide may be used as a derivatizing reagent for the determination of methionine sulfoxide and methionine in blood plasma and chlorpyrifos, diazinon and their major metabolites in sludge and sludge-fertilized agricultural soils using gas-chromatography coupled to mass spectrometry technique.
Legal Information
LiChropur is a trademark of Merck KGaA, Darmstadt, Germany
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signalword
Warning
hcodes
Hazard Classifications
Flam. Liq. 3
Storage Class
3 - Flammable liquids
wgk
WGK 3
flash_point_f
113.0 °F - closed cup
flash_point_c
45 °C - closed cup
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