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F7503

Formamide

ReagentPlus®, ≥99.0% (GC)

Synonym(s):

Amide C1, Formic amide

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About This Item

Linear Formula:
HCONH2
CAS Number:
75-12-7
Molecular Weight:
45.04
UNSPSC Code:
12352111
NACRES:
NA.21
PubChem Substance ID:
329799765
EC Number:
200-842-0
Beilstein/REAXYS Number:
505995
MDL number:
MFCD00007941
Assay:
≥99.0% (GC)
Technique(s):
hybridization: suitable
Bp:
210 °C (lit.)
Vapor pressure:
0.08 mmHg ( 20 °C), 30 mmHg ( 129 °C)
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vapor density

1.55 (vs air)

Quality Segment

100

vapor pressure

0.08 mmHg ( 20 °C), 30 mmHg ( 129 °C)

product line

ReagentPlus®

assay

≥99.0% (GC)

form

liquid

autoignition temp.

932 °F

expl. lim.

2.7-19 %

technique(s)

hybridization: suitable

refractive index

n20/D 1.447 (lit.)

pH

4-10 (20 °C, 200 g/L)

bp

210 °C (lit.)

mp

2-3 °C (lit.)

density

1.134 g/mL at 25 °C (lit.)

SMILES string

NC=O

InChI

1S/CH3NO/c2-1-3/h1H,(H2,2,3)

InChI key

ZHNUHDYFZUAESO-UHFFFAOYSA-N

General description

Formamide is a polar solvent mainly used for resins and plasticizers. It can be prepared by direct synthesis from carbon monoxide and ammonia.

Application

Formamide can be used as a solvent:
  • To synthesize tetrakis(trialkylsilyl) diphosphate by reacting disodium dihydrogen diphosphate with trialkyl chlorosilane.
  • In Cu/C catalyzed cycloaddition between azides and terminal alkynes to synthesize triazoles.
Formamide destabilizes nucleic acid duplexes and may be used, typically, at a concentration of 50%, in hybridization protocols requiring lower hybridization temperatures.

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

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pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Carc. 2 - Repr. 1B - STOT RE 2 Oral

target_organs

Blood

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

305.6 °F

flash_point_c

152 °C

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