114825 Sigma-AldrichAdapalene - CAS 106685-40-9 - Calbiochem
A cell-permeable naphthoic acid compound that exhibits selective affinity and agonistic potency toward RARβ and RARγ over RARα.
More>> A cell-permeable naphthoic acid compound that exhibits selective affinity and agonistic potency toward RARβ and RARγ over RARα. Less<<Adapalene - CAS 106685-40-9 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Synonymes: Differin, 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid, CD 271, CD271, RAR Agonist V, ADA
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Aperçu
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Tableau de caractéristiques principal
| CAS # | Empirical Formula |
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| 106685-40-9 | C₂₈H₂₈O₃ |
Products
| Référence | Conditionnement | Qté | |
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| 114825-25MG | 25 mg |
| Description | |
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| Overview | A cell-permeable naphthoic acid compound that exhibits selective affinity and agonistic potency toward RARβ and RARγ over RARα (Kd = 34, 130, and 1100 nM, respectively; AC50 = 2.3, 9.3, and 22 nM, respectively, in COS-7-based reporter assays) without appreciable affinity toward cytosolic retinoic acid binding proteins CRABP I/II (Kd >> 1 µM) or detectable activity toward RXRα (AC50 > 1 µM). The biological activity and pharmaceutical efficacy of ADA are generally shown to be superior to those of ATRA/Tretinoin (Cat. No. 554720) both in vitro and in vivo. |
| Catalogue Number | 114825 |
| Brand Family | Calbiochem® |
| Synonyms | Differin, 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid, CD 271, CD271, RAR Agonist V, ADA |
| Product Information | |
|---|---|
| CAS number | 106685-40-9 |
| Form | White solid |
| Hill Formula | C₂₈H₂₈O₃ |
| Chemical formula | C₂₈H₂₈O₃ |
| Structure formula Image | |
| Quality Segment | MQ100 |
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| Biological Information | |
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| Purity | ≥97% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Référence | GTIN |
| 114825-25MG | 04055977208122 |
Documentation
Required Licenses
| Title |
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| PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD |
Adapalene - CAS 106685-40-9 - Calbiochem FDS
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Adapalene - CAS 106685-40-9 - Calbiochem Certificats d'analyse
| Titre | Numéro de lot |
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| 114825 |
Références bibliographiques
| Aperçu de la référence bibliographique |
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| Irby, C.E., et al. 2008. J. Adolesc. Health 43, 421. Ocker, M., et al. 2003. Int. J. Cancer 107, 453. Kim, M.J., et al. 2000. J. Invest. Dermatol. 114, 349. Shroot, B., et al. 1997. J. Am. Acad. Dermatol. 36, S96. |
Brochure
| Titre |
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| SQ Test Kits Power Generation Plant |
| Undisputed Accuracy for Your Quantitative Results |
Informations techniques
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| Programming data for Spectrophotometer and Spectroquant Test Kits |
Manuels d'utilisation
Notices insérées avec les produits
| Titre |
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| Spectroquant®Prove Quick Guide - Chinese Simplified |