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Merck

108448

Cyanoacetamide

99%

Synonym(s):

2-Cyanoacetamide

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About This Item

Linear Formula:
NCCH2CONH2
CAS Number:
107-91-5
Molecular Weight:
84.08
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
24846668
EC Number:
203-531-8
Beilstein/REAXYS Number:
878221
MDL number:
MFCD00008024

Key Documents

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InChI key

DGJMPUGMZIKDRO-UHFFFAOYSA-N

InChI

1S/C3H4N2O/c4-2-1-3(5)6/h1H2,(H2,5,6)

SMILES string

NC(=O)CC#N

assay

99%

Quality Level

200

solubility

cold water: soluble 1gm in 6.5ml

functional group

amide, nitrile

Related Categories

General description

Cyanoacetamide is the starting reagent for vitamin B6 synthesis. It reacts with reducing carbohydrates in borate buffer to give intense fluorescence andis useful for the automated analysis of carbohydrates as borate complexes.

Cyanoacetamide is a highly reactive compound used as a reaction intermediate in condensation and substitution reactions.

Application

Cyanoacetamide was used in spectrofluorimetric method for the determination of some antihistaminic H1 receptor antagonist drugs such as ebastine, cetirizine dihydrochloride and fexofenadine hydrochloride. It may be used in fluorometric determination of 3,4-dihydroxyphenylalanine. It was used as post column fluorigenic derivatizing agent for the bio-analysis and pharmacokinetics of chitosan ester in rabbit serum.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

419.0 °F - closed cup

flash_point_c

215 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Deleterious substance

pdsc

108448-100G:4548173102436 + 108448-5G:4548173102450 + 108448-500G:4548173102443 + 108448-VAR: + 108448-BULK:

jan

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Certificates of Analysis (COA)

Lot/Batch Number
WXBD6820V
WXBD4092V
WXBD1966V
WXBC9074V
WXBC7475V

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Hao Chen et al.
Scientific reports, 8(1), 13433-13433 (2018-09-09)
Early damage to transplanted organs initiates excess inflammation that can cause ongoing injury, a leading cause for late graft loss. The endothelial glycocalyx modulates immune reactions and chemokine-mediated haptotaxis, potentially driving graft loss. In prior work, conditional deficiency of the
Fluorimetric determination of reducing carbohydrates with 2-cyanoacetamide and application to automated analysis of carbohydrates as borate complexes.
Honda S, et al.
Analytical Chemistry, 52(7), 1079-1082 (1980)
Fluorometric determination of 3, 4-dihydroxyphenylalanine with 2-cyanoacetamide.
Liu Y, et al.
Journal of Fluorescence, 13(2), 123-128 (2003)
Spectrofluorimetric Determination Of Some H1 Receptor Antagonist Drugs In Pharmaceutical Formulations And Biological Fluids.
Ibrahim F, et al.
International Journal of Pharmaceutical Sciences and Research, 2(8), 2056-2072 (2011)
Gregg A Duncan et al.
Molecular therapy. Methods & clinical development, 9, 296-304 (2018-07-25)
Diffusion of the viral vectors evaluated in inhaled gene therapy clinical trials to date are largely hindered within airway mucus, which limits their access to, and transduction of, the underlying airway epithelium prior to clearance from the lung. Here, we
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Articles

Knoevenagel Condensation Reaction

Knoevenagel Condensation is an organic reaction named after Emil Knoevenagel. It is a classic C-C bond formation reaction and a modification of the Aldol Condensation.

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