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157260

1-Hydroxybenzotriazole hydrate

Name: 1-Hydroxybenzotriazole hydrate
Brand: ALDRICH

98% dry basis wetted with not less than 14 wt. % water, for peptide synthesis

Synonym(s):

HOBt Hydrate

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About This Item

Empirical Formula (Hill Notation):

C₆H₅N₃O · xH₂O

CAS Number:

123333-53-9

Molecular Weight:

135.12 (anhydrous basis)

MDL number:

MFCD00065690

UNSPSC Code:

12352000

PubChem Substance ID:

24849666

NACRES:

NA.22

EC Number:

219-989-7

Beilstein/REAXYS Number:

4515

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Properties

Product Name

1-Hydroxybenzotriazole hydrate, wetted with not less than 14 wt. % water, 98% dry basis

Quality Level

200

assay

98% dry basis

form

solid

quality

synthesis grade

reaction suitability

reaction type: Addition Reactions

mp

155-158 °C (lit.)

application(s)

peptide synthesis

SMILES string

[H]O[H].On1nnc2ccccc12

InChI

1S/C6H5N3O.H2O/c10-9-6-4-2-1-3-5(6)7-8-9;/h1-4,10H;1H2

InChI key

PJUPKRYGDFTMTM-UHFFFAOYSA-N

Description

General description

1-Hydroxybenzotriazole hydrate is a derivative of benzotriazole primarily used as a coupling reagent in peptide synthesis.

Application

1-Hydroxybenzotriazole hydrate can be used as a reagent:

To synthesize β-peptides via microwave-assisted amino acid coupling.
In the spot synthesis of glycopeptides.

It can also be used as a deprotection agent for the removal of Fmoc (9-fluorenylmethoxycarbonyl) protecting group.

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pictograms

GHS02,GHS07

signalword

Danger

hcodes

H207,H319,H412

pcodes

P210 - P212 - P230 - P233 - P280 - P370 + P380 + P375 - P501

Hazard Classifications

Aquatic Chronic 3 - Desen. Expl. 2 - Eye Irrit. 2

supp_hazards

EUH044

Storage Class

4.1A - Other explosive hazardous materials

wgk

WGK 1

flash_point_f

314.6 °F

flash_point_c

157 °C

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Group 5: Self-reactive substances + Hydrazine derivates + Hazardous rank I + 1st self-reactive materials

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