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437727

Tetrahydrofuran-d8

≥99.5 atom % D, contains 0.03 % (v/v) TMS

Synonym(s):

THF-d8, Deuterated tetrahydrofuran, Octadeuterotetrahydrofuran

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About This Item

Linear Formula:
(CD2)4O
CAS Number:
1693-74-9
Molecular Weight:
80.16
UNSPSC Code:
12142201
NACRES:
NA.21
PubChem Substance ID:
24867392
MDL number:
MFCD00044238
Beilstein/REAXYS Number:
111854
Isotopic purity:
≥99.5 atom % D
Assay:
≥99% (CP)
Mass shift:
M+8
Form:
liquid
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isotopic purity

≥99.5 atom % D

Quality Segment

200

assay

≥99% (CP)

form

liquid

contains

0.03 % (v/v) TMS

technique(s)

NMR: suitable

impurities

≤0.03% water
water

refractive index

n20/D 1.403 (lit.)

bp

65-66 °C (lit.)

mp

−106 °C (lit.)

density

0.985 g/mL at 25 °C (lit.)

mass shift

M+8

storage temp.

2-8°C

SMILES string

[2H]C1([2H])OC([2H])([2H])C([2H])([2H])C1([2H])[2H]

InChI

1S/C4H8O/c1-2-4-5-3-1/h1-4H2/i1D2,2D2,3D2,4D2

InChI key

WYURNTSHIVDZCO-SVYQBANQSA-N

General description

Tetrahydrofuran-d8 (THF-d8, TDF) is a deuterated NMR solvent containing 0.03% (v/v) TMS (tetramethylsilane). It is useful in NMR-based research and analyses. 1H NMR line shape analysis of the exchange rates of proton between methanol and acetic acid dissolved in THF-d8 was reported. It participates as a solvent in the synthesis of deuteriotris[bis(trimethylsilyl)amido]thorium and deuteriotris[bis(trimethylsiiyl)amido]uranium. Dynamic NMR spectroscopic study of 15N,15N′-dipentadeuterophenylformamidine (DPFA) has been studied in THF-d8.

Application


  • Experimental and Theoretical Study of CO2 Insertion into Ruthenium Hydride Complexes.: This research provides insights into the mechanistic pathways for CO2 reactivity with ruthenium hydride complexes, potentially relevant for catalytic applications including transformations involving Tetrahydrofuran-d₈ (Ramakrishnan et al., 2016).


  • Syntheses, structures, and NMR chemical shifts of a family of trimethyltin alkoxide, amide, halide and cyclopentadienyl compounds.: Details the synthesis and structural characterization of trimethyltin compounds, useful for understanding the coordination chemistry that may involve Tetrahydrofuran-d₈ as a solvent or structural analogue (Lichtscheidl et al., 2015).

  • NMR studies of coupled low- and high-barrier hydrogen bonds in pyridoxal-5′-phosphate model systems in polar solution.: Discusses the application of NMR spectroscopy in studying hydrogen bonding interactions, where Tetrahydrofuran-d₈ could be utilized as a deuterated solvent for enhanced spectral clarity (Sharif et al., 2007).


  • Stable hydrocarbon diradical, an analogue of trimethylenemethane.: Investigates stable hydrocarbon diradicals, where Tetrahydrofuran-d₈ may be used as part of the experimental setup to stabilize reactive intermediates or as a solvent to study radical stability (Rajca et al., 2005).


Other Notes

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Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

target_organs

Central nervous system, Respiratory system

supp_hazards

EUH019

Storage Class

3 - Flammable liquids

wgk

WGK 1

flash_point_f

1.4 °F - closed cup

flash_point_c

-17 °C - closed cup

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Class I Designated Chemical Substances

prtr

Group 4: Flammable liquids + Type 1 petroleums + Hazardous rank II + Water soluble liquid

fsl

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

437727-5G:4.548173150291E12 + 437727-10G:4.548173150277E12 + 437727-1G:4.548173150284E12

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