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Merck

467804

Hydroxylamine solution

50 wt. % in H2O, 99.999%

Synonym(s):

HDA

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About This Item

Linear Formula:
NH2OH
CAS Number:
7803-49-8
Molecular Weight:
33.03
NACRES:
NA.22
PubChem Substance ID:
24870439
UNSPSC Code:
12352116
EC Number:
232-259-2
MDL number:
MFCD00044522
Assay:
99.999%

Key Documents

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InChI key

AVXURJPOCDRRFD-UHFFFAOYSA-N

InChI

1S/H3NO/c1-2/h2H,1H2

SMILES string

NO

assay

99.999%

concentration

50 wt. % in H2O

bp

107 °C

density

1.078 g/mL at 25 °C

Quality Level

100

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General description

Hydroxylamine solution is widely used as a reducing agent and antioxidant in organic synthesis, polymer industry and water treatment.

Application

Hydroxylamine solution (NH2OH) can be used as a reactant for the preparation of:
  • Primary amides from aldehydes catalyzed by an arene–ruthenium(II) complex.
  • Hydroxyaminoguanidines and carboxamide derivatives of ofloxacin for biological studies.
  • Fe3O4/Au (GoldMag) nanoparticles for antibody immobilization.

Reactant for preparation of:
  • Prodrug for cardiovascular agent Nω-hydroxy-L-arginine (NOHA, nitric oxide precursor)
  • Hydroxyaminoguanidines as anti-cancer agents
  • Nonsteroidal 2,3-dihydroquinoline glucocorticoid receptor agonists with reduced phosphoenolpyruvate caboxykinase (PEPCK) transactivation
  • Carboxamide derivatives of ofloxacin with improved antimicrobial properties
  • Analogues of coumarin based TNF-α converting enzyme (TACE) inhibitors
  • HIV integrase inhibitors

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Carc. 2 - Desen. Expl. 4 - Eye Dam. 1 - Met. Corr. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 - STOT SE 3

target_organs

Blood, Respiratory system

Storage Class

3 - Flammable liquids

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Deleterious substance

pdsc

Group 5: Self-reactive substances + Materials containing Hydroxylamine + Hazardous rank II + 2nd self-reactive materials

fsl

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

467804-10ML:4548173155524 + 467804-BULK: + 467804-50ML:4548173155531 + 467804-VAR:

jan

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Certificates of Analysis (COA)

Lot/Batch Number
STBK6006
STBJ9216
STBJ0968
STBH7727
STBH1572

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Ruthenium-catalyzed one-pot synthesis of primary amides from aldehydes in water
Garcia-Alvarez R, et al.
Royal Society of Chemistry Advances, 3(17), 5889-5894 (2013)
Synthesis, characterization and biological activity of a series of carboxamide derivatives of ofloxacin
Arayne MS, et al.
Archives of Pharmacal Research, 33(12), 1901-1909 (2010)
N-Hydroxy-N′-aminoguanidines as anti-cancer lead molecule: QSAR, synthesis and biological evaluation
Basu A, et al.
Bioorganic & Medicinal Chemistry Letters, 21(11), 3324-3328 (2011)
The synthesis of GoldMag nano-particles and their application for antibody immobilization
Cui Y, et al.
Biomedical Microdevices, 7(2), 153-156 (2005)
A E Cribb et al.
Clinical pharmacology and therapeutics, 51(5), 522-526 (1992-05-01)
The oxidation of sulfamethoxazole to its hydroxylamine metabolite was investigated in vitro with human liver microsomes and in vivo by detection in the urine. Sulfamethoxazole was oxidized to the hydroxylamine in an NADPH-dependent process by liver microsomes prepared from two
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