656984
Isopropylmagnesium chloride lithium chloride complex solution
1.3 M in THF
Synonym(s):
Turbo Grignard
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About This Item
reaction suitability
reaction type: Grignard Reaction
Quality Level
packaging
Sure/Seal™ of
concentration
1.3 M in THF
density
0.951 g/mL at 25 °C
SMILES string
[Li]Cl.CC(C)[Mg]Cl
InChI
1S/C3H7.2ClH.Li.Mg/c1-3-2;;;;/h3H,1-2H3;2*1H;;/q;;;2*+1/p-2
InChI key
CWTUREABAILGIK-UHFFFAOYSA-L
Application
Used for:
- Preparation of functionalized acyclic alkenyl magnesium reagents/preparation of 1,2-diketones
- Preparation of cyclic alkenyl and dienyl magnesium reagents
- Preparation of functionalized triazenes/preparation of carbazoles
- Regioselective functionalization of trisubstituted pyridines
- Electrophilic amination for preparation of amines
- Preparation of Grignards reagents in the presence of masked ketones and aldehydes (using readily deprotectable silylated cyanohydrins)
- Preparation of Benzylic Grignards via Sulfur-Magnesium exchange
- Functionalization via I-Mg Exchange of unprotected aromatic and heteroaromatic carboxylic acids
- Functionalization via I-Mg Exchange of unprotected imidazoles
- Pyridyne formation
- Functionalization of cyclopentene derivatives
- Preparation of 2,3-functionalized furans, benzofurans, and thiophenes
- Stereoselective synthesis of substituted cyclopropanes
Packaging
Legal Information
signalword
Danger
hcodes
Hazard Classifications
Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 3
target_organs
Central nervous system, Respiratory system
supp_hazards
Storage Class
3 - Flammable liquids
flash_point_f
1.4 °F
flash_point_c
-17 °C
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Regulatory Listings
Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.
Class I Designated Chemical Substances
prtr
Group 3: Spontaneously combustible substances and water- reactive materials + Materials containing Organometallic compounds + Hazardous rank I + 1st spontaneously combustible materials and water reactive materials
fsl
Substances Subject to be Indicated Names
ishl_indicated
Substances Subject to be Notified Names
ishl_notified
656984-100ML:4.5481732248E12 + 656984-2L:4.548173912554E12 + 656984-800ML:4.548173300207E12 + 656984-10ML:4.548173224817E12
jan
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Articles
Transformative reagents enable selective conversions within molecules containing sensitive functionalities under mild reactions.
Salt additives increase both the rate and the efficiency of the Mg-halogen exchange reaction. The most effective reagents are generated with R-MgCl (R = i-Pr, s-Butyl) and 1.0 equiv of LiCl.