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Merck

700312

Iron oxide(II,III), magnetic nanoparticles solution

10 nm avg. part. size, 5 mg/mL in toluene

Synonym(s):

Magnetic iron oxide nanocrystals, Magnetite, Superparamagnetic iron oxide nanoparticles

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About This Item

Empirical Formula (Hill Notation):
Fe3O4
CAS Number:
1317-61-9
Molecular Weight:
231.53
NACRES:
NA.23
PubChem Substance ID:
329762195
UNSPSC Code:
12352302
MDL number:
MFCD00011010

Key Documents

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Quality Level

100

InChI

1S/3Fe.4O

SMILES string

O=[Fe].O=[Fe]O[Fe]=O

InChI key

SZVJSHCCFOBDDC-UHFFFAOYSA-N

form

nanoparticles, solution

concentration

5 mg/mL in toluene

magnetization

>45 emu/g (at ambient temperature under 4500 Oe)

avg. part. size

10 nm

particle size

9-11 nm (TEM; conforms)

density

0.865 g/mL at 25 °C

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General description

Concentration 5mg/ml includes total weight nanocrystals plus ligands.
Iron oxide(II,III), magnetic nanoparticles solution (Fe3O4) is an organic solvent dispersed nanoparticle solution, which can be synthesized by the thermal decomposition of iron acetylacetonate in 2-pyrrolidone. It is majorly used in biomedical applications due to its magnetic properties, particle size, and surface properties.
It contains <1.0% oleic acid stabilizing ligands.

Application

Fe3O4 can be used in the targeting and imaging of tumor cells for cancer therapy-based applications. It may also be used in the separation of tumor cells from fresh whole blood. It can also be used as an effective material in drug delivery systems and magnetic resonance imaging (MRI).

signalword

Danger

Hazard Classifications

Aquatic Chronic 3 - Asp. Tox. 1 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 2 - STOT SE 3

target_organs

Central nervous system

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

45.0 °F

flash_point_c

7.2 °C

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Class I Designated Chemical Substances

prtr

Group 4: Flammable liquids + Type 1 petroleums + Hazardous rank II + Water insoluble liquid

fsl

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

700312-5ML:4548173293349 + 700312-VAR: + 700312-BULK:

jan

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Certificates of Analysis (COA)

Lot/Batch Number
MKCQ3040
MKCM5927
MKCK4363
MKBZ5894V
MKBZ1033V

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Nonpolymeric coatings of iron oxide colloids for biological use as magnetic resonance imaging contrast agents
Portet D, et al.
Journal of Colloid and Interface Science, 238(1), 37-42 (2001)
Superparamagnetic nanoparticles for biomedical applications: possibilities and limitations of a new drug delivery system
Neuberger T, et al.
Journal of magnetism and magnetic materials, 293(1), 483-496 (2005)
Antibody conjugated magnetic iron oxide nanoparticles for cancer cell separation in fresh whole blood
Xu H, et al.
Biomaterials, 32(36), 9758-9765 (2011)
Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy
Peng X, et al.
International journal of nanomedicine, 3(3), 311-311 (2008)
Synthesis of Fe3O4 nanoparticles with various sizes and magnetic properties by controlled hydrolysis
Iida H, et al.
Journal of Colloid and Interface Science, 314(1), 274-280 (2007)
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