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Merck

704105

Polycaprolactone

average Mn 45,000

Synonym(s):

2-Oxepanone homopolymer, 6-Caprolactone polymer

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About This Item

Linear Formula:
(C6H10O2)n
NACRES:
NA.21
UNSPSC Code:
12162002

Key Documents

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form

pellets

melt index

1.8 g/10 min (80 °C, 44 psi)

mol wt

Mn 40,000-50,000, Mw 48,000-90,000, average Mn 45,000

mp

56-64 °C, 60 °C (lit.)

Quality Level

100

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General description

Polycaprolactone (PCL) is a semi-crystalline linear resorbable aliphatic polyester that is composed of repeating units of hexanoate. It has good mechanical properties, miscibility, and biodegradability. PCL is a soft and hard-tissue compatible material that can be used in sutures and drug delivery systems.

Application

PCL can form a nanocomposite with graphene for the fabrication of biodegradable systems for bone tissue engineering.

Features and Benefits

Biodegradable polymer
Non-toxic, biodegradable in soil, broad miscibility, mechanical compatibility with many polymers and good adhesion to a broad spectrum of substrates.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

704105-BULK: + 704105-100G: + 704105-500G: + 704105-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
MKCM9356
MKCL2159
MKCH9530
MKCD3536
MKCC3512

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A novel degradable polycaprolactone networks for tissue engineering
Kweon H, et al.
Biomaterials, 24(5), 801-808 (2003)
Bone tissue engineering using polycaprolactone scaffolds fabricated via selective laser sintering
Williams JM, et al.
Biomaterials, 26(23), 4817-4827 (2005)
Synthesis of polycaprolactone: a review
Labet M and Thielemans W
Chemical Society Reviews, 38(12), 3484-3504 (2009)
Properties of thermoplastic blends: starch-polycaprolactone
Averous L, et al.
Polymer, 41(11), 4157-4167 (2000)
Wendi Zhang et al.
Biomaterials, 34(27), 6495-6503 (2013-06-04)
Coating the polycation/DNA binary complexes with PEGylated polyanions can improve long-circulation and biocompatibility in vivo. However, it has been certificated PEG dilemma can reduces gene transfection efficiency because of inhibition in cellular uptake and endosomal escape. Herein, two PEGylated anionic
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