764752
Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)
PEG average Mn 5,000, PLGA Mn 55,000
Synonym(s):
PEG-PLGA, Polyethylene glycol, mPEG-b-PLGA, mPEG-b-PLGA
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About This Item
Linear Formula:
H[(C3H4O2)x(C2H2O2)y]mO[C2H4O]nCH3
NACRES:
NA.23
UNSPSC Code:
12162002
description
typical PEG PDI < 1.1; overall PDI < 2.5
Quality Level
form
pellets
feed ratio
lactide:glycolide 50:50
mol wt
PEG average Mn 5,000, PLGA Mn 55,000, average Mn 60,000 (total)
degradation timeframe
1-4 weeks
transition temp
Tg 10 °C(lit.), Tm 254-259 °C
PDI
<1.2
storage temp.
2-8°C
General description
Amphiphilic block copolymers (AmBC) are made up of two chemically different homopolymer blocks. One of the block is hydrophilic and the other one is hydrophobic. These macromolecules have the properties to self-assemble when dissolved in an aqueous media. PEG-PLGA is one the most commonly used biodegradable amphiphilic block copolymers for drug delivery applications. PEG is the hydrophilic part and PLGA is the hydrophobic part.
Application
Used in the synthesis of targeted nanoparticles which are used for differential delivery and controlled release of drugs.
Features and Benefits
- Good biocompatibility, low immunogenicity and good degradability.
- Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Articles
マイクロ流体技術を利用した、薬物送達用に設計されたナノ担体として知られるナノ材料のさまざまな調製法について解説します。
ポリラクチドおよびポリグリコリドを含む脂肪族ポリエステルは、医療用途に広く使用されている生分解性ポリマーです。
ポリマーソームの合成および、ポリマーソーム標的化を実現するための表面修飾と、薬物放出の制御のための動的または刺激応答性の化学的手段の組込みについて概説します。
Thermosensitive self-assembling block copolymers as drug delivery systems
Bonacucina, G., Cespi, M., Mencarelli, G., Giorgioni, G., & Palmieri, G. F.
Polymers (Basel, Switzerland), 3(2), 779-811 (2011)
Hunter Bachman et al.
Lab on a chip, 20(7), 1238-1248 (2020-02-28)
Whether reagents and samples need to be combined to achieve a desired reaction, or precise concentrations of solutions need to be mixed and delivered downstream, thorough mixing remains a critical step in many microfluidics-based biological and chemical assays and analyses.
Frank Gu et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(7), 2586-2591 (2008-02-15)
There has been progressively heightened interest in the development of targeted nanoparticles (NPs) for differential delivery and controlled release of drugs. Despite nearly three decades of research, approaches to reproducibly formulate targeted NPs with the optimal biophysicochemical properties have remained