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Merck

765139

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)

PEG average Mn 5,000, PLGA Mn 7,000

Synonym(s):

PEG-PLGA, Polyethylene glycol, mPEG-b-PLGA

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About This Item

Linear Formula:
H[(C3H4O2)x(C2H2O2)y]mO[C2H4O]nCH3
NACRES:
NA.23
UNSPSC Code:
12162002

Key Documents

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form

solid

Quality Level

100

feed ratio

lactide:glycolide 50:50

mol wt

PEG average Mn 5,000, PLGA Mn 7,000, average Mn 12,000 (total)

degradation timeframe

1-4 weeks

transition temp

Tg 24 °C, Tm 38-43 °C

PDI

<2.0

storage temp.

2-8°C

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General description

Amphiphilic block copolymers (AmBC) are made up of two chemically different homopolymer blocks. One of the block is hydrophilic and the other one is hydrophobic. These macromolecules have the properties to self-assemble when dissolved in an aqueous media. PEG-PLGA is one the most commonly used biodegradable amphiphilic block copolymers for drug delivery applications. PEG is the hydrophilic part and PLGA is the hydrophobic part.

Application

forming "stealth" pegylated microparticles
Used in the synthesis of targeted nanoparticles which are used for differential delivery and controlled release of drugs.

Features and Benefits

  • Good biocompatibility, low immunogenicity and good degradability.
  • Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

No data available

flash_point_c

No data available

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

765139-1G: + 765139-BULK: + 765139-VAR:

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Thermosensitive self-assembling block copolymers as drug delivery systems.
Bonacucina, G., Cespi, M., Mencarelli, G., Giorgioni, G., &amp; Palmieri, G. F.
Polymer, 3(2), 779-811 (2011)
Frank Gu et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(7), 2586-2591 (2008-02-15)
There has been progressively heightened interest in the development of targeted nanoparticles (NPs) for differential delivery and controlled release of drugs. Despite nearly three decades of research, approaches to reproducibly formulate targeted NPs with the optimal biophysicochemical properties have remained
PLGA-PEG Encapsulated sitamaquine nanoparticles drug delivery system against Leishmania donovani
Kumara, R., Sahoo, G. C., Pandeya, K., Dasa, V. N. R., Yousuf, M., Ansaria, S. R., &amp; Dasa, P.
Journal of Scientific and Innovative Research, 3(1), 85-90 (2014)

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