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Merck

765147

2-Nitro-5-(2-propynyloxy)benzyl 4-cyano-4-(phenylcarbonothioylthio)pentanoate

97%

Synonym(s):

Clickable CTA, Light-sensitive clickable RAFT agent, RAFT agent

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About This Item

Empirical Formula (Hill Notation):
C23H20N2O5S2
CAS Number:
1318075-32-9
Molecular Weight:
468.55
UNSPSC Code:
12352100
PubChem Substance ID:
329767158
MDL number:
MFCD28098662

Key Documents

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InChI

1S/C23H20N2O5S2/c1-3-13-29-19-9-10-20(25(27)28)18(14-19)15-30-21(26)11-12-23(2,16-24)32-22(31)17-7-5-4-6-8-17/h1,4-10,14H,11-13,15H2,2H3

SMILES string

C#CCOC1=CC(COC(CCC(C)(C#N)SC(C2=CC=CC=C2)=S)=O)=C([N+]([O-])=O)C=C1

InChI key

IOYDTDXAMFFKOA-UHFFFAOYSA-N

assay

97%

form

solid

mp

90-94 °C

storage temp.

2-8°C

General description

Need help choosing the correct RAFT Agent? Please consult the RAFT Agent to Monomer compatibility table.

Application

RAFT agent for controlled radical polymerization; especially suited for the polymerization of methacrylate and methacrylamide monomers. Chain Transfer Agent (CTA) with alkyne functionality for ligation and a photo-sensitive moiety for controlled cleavage.

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

Hazard Classifications

Aquatic Acute 1 - Eye Irrit. 2 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Deleterious substance

pdsc

765147-1G:4548173318202 + 765147-VAR: + 765147-BULK:

jan

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Certificates of Analysis (COA)

Lot/Batch Number
MKBL5289

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Zahra Abousalman-Rezvani et al.
Carbohydrate polymers, 225, 115247-115247 (2019-09-16)
Cellulose nanocrystals (CNC)-grafted and free copolymers were synthesized in three different ratios of DMAEMA and coumarin monomers (30:5, 40:7, and 50:10) through reversible addition-fragmentation chain transfer polymerization. These multi-responsive polymers to carbon dioxide (CO2), temperature, and light triggers can be
Lida Ahmadkhani et al.
Artificial cells, nanomedicine, and biotechnology, 46(5), 1052-1063 (2017-07-30)
A drug delivery system based on dual responsive units was developed. An appealing pH- and thermo-responsive triblock terpolymer as the drug carrier was synthesized by RAFT polymerization of N-isopropyl acrylamide and methacrylic acid monomers using PEG-RAFT agent. The Fe3O4 magnetic
Mirim Park et al.
Macromolecular rapid communications, 41(20), e2000399-e2000399 (2020-09-10)
Redox-initiated reversible addition-fragmentation chain transfer (RAFT) miniemulsion polymerizations are successfully conducted with an employment of trithiocarbonate-based macro-RAFT agents and surfactant. Two macro-RAFT agents-hydrophilic poly(poly(ethylene glycol) methyl ether methacrylate) (PPEGMA27 ) and amphiphilic poly(poly(ethylene glycol) methyl ether methacrylate)-b-polystyrene (PPEGMA27 -b-PS33 )-
Shunsuke Tazawa et al.
Macromolecular rapid communications, 41(19), e2000346-e2000346 (2020-08-19)
Thermoplastic solid poly(2-methoxyethyl acrylate) (PMEA)-based polyurethane (PU) is synthesized through the reversible addition-fragmentation chain transfer (RAFT) polymerization and the condensation polymerization, using hydroxyl-terminated RAFT reagents and diisocyanate, respectively. Neat PMEA is a promising antithrombogenic liquid used in the medical fields.
Thomas Swift et al.
Soft matter, 12(9), 2542-2549 (2016-01-30)
Fluorescence spectroscopy on a series of aqueous solutions of poly(acrylic acid) containing a luminescent label showed that polymers with molar mass, Mn < 16.5 kDa did not exhibit a pH responsive conformational change, which is typical of higher molar mass
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ペプチドやタンパク質のような生体高分子に合成ポリマーを結合させて修飾することで、特性が強化された極めて高度な新しい種類の生体材料が得られています。

Protein- and Peptide- Polymer Conjugates by RAFT Polymerization

The modification of biomacromolecules, such as peptides and proteins, through the attachment of synthetic polymers has led to a new family of highly advanced biomaterials with enhanced properties.

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