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Merck

81300

Poly(ethylene glycol)

greener alternative

average MN 20,000, hydroxyl

Synonym(s):

Polyethylene glycol, PEG

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About This Item

Linear Formula:
H(OCH2CH2)nOH
CAS Number:
25322-68-3
UNSPSC Code:
12352104
PubChem Substance ID:
24887748
NACRES:
NA.23
MDL number:
MFCD00081839

Key Documents

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Product Name

Poly(ethylene glycol), average Mn 20,000

InChI

1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

InChI key

LYCAIKOWRPUZTN-UHFFFAOYSA-N

form

flakes

mol wt

average Mn 20,000

greener alternative product characteristics

Safer Solvents and Auxiliaries
Learn more about the Principles of Green Chemistry.

sustainability

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mp

63-66 °C

Ω-end

hydroxyl

α-end

hydroxyl

greener alternative category

Aligned

Quality Level

200

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General description

Polyethylene glycol (PEG) is a hydrophilic polymer. It can be easily synthesized by the anionic ring opening polymerization of ethylene oxide, into a range molecular weights and variety of end groups. When crosslinked into networks PEG can have high water content, forming “hydrogels”. Hydrogel formation can be initiated by either crosslinking PEG by ionizing radiation or by covalent crosslinking of PEG macromers with reactive chain ends. PEG is a suitable material for biological applications because it does not trigger an immune response.
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Green Chemistry. Polyethylene glycol (PEG) is an eco-friendly, biodegradable polymer widely used in pharmaceuticals and cosmetics. Its non-toxic nature and versatility make it a sustainable choice, derived from renewable resources, contributing to greener product formulations. Click here for more information.

Application

PEG has been used to modify therapeutic proteins and peptides to increase their solubility and lower their toxicity.

Photopolymerized PEG hydrogels have emerging applications in the fabrication of bioactive and immunoisolating barriers for encapsulation of cells.

Other Notes

Molecular weight: Mn 16,000-24,000

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

81300-VAR: + 81300-5KG: + 81300-1KG: + 81300-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG4865
BCCG4864
BCCF7279
BCCF7277
BCCD8215

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Xu Zhang et al.
Langmuir : the ACS journal of surfaces and colloids, 28(40), 14330-14337 (2012-09-20)
Understanding the interface between DNA and nanomaterials is crucial for rational design and optimization of biosensors and drug delivery systems. For detection and delivery into cells, where high concentrations of cellular proteins are present, another layer of complexity is added.
Chien-Chi Lin et al.
Biomaterials, 32(36), 9685-9695 (2011-09-20)
Hydrogels provide three-dimensional frameworks with tissue-like elasticity and high permeability for culturing therapeutically relevant cells or tissues. While recent research efforts have created diverse macromer chemistry to form hydrogels, the mechanisms of hydrogel polymerization for in situ cell encapsulation remain
Carrie F Olson-Manning
Molecular biology and evolution, 37(8), 2257-2267 (2020-03-21)
Metabolic networks are complex cellular systems dependent on the interactions among, and regulation of, the enzymes in the network. Although there is great diversity of types of enzymes that make up metabolic networks, the models meant to understand the possible
Teagan E Bate et al.
Soft matter, 15(25), 5006-5016 (2019-06-06)
Self-organization of kinesin-driven, microtubule-based 3D active fluids relies on the collective dynamics of single microtubules. However, the connection between macroscopic fluid flows and microscopic motion of microtubules remains unclear. In this work, the motion of single microtubules was characterized by
Idalis Villanueva et al.
Acta biomaterialia, 5(8), 2832-2846 (2009-06-11)
The pericellular matrix (PCM) surrounding chondrocytes is thought to play an important role in transmitting biochemical and biomechanical signals to the cells, which regulates many cellular functions including tissue homeostasis. To better understand chondrocytes interactions with their PCM, three-dimensional poly(ethylene
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Articles

ポリエチレングリコール（PEG）：DDSと組織工学での活用・選択ガイド

ポリエチレングリコール（PEG）は、生物学的、化学的応用や医薬品開発に有用な化学的性質を有するエチレンオキシドと水との縮合ポリマーです。研究用途にPEGを使用する際に考慮すべき4つのポイントをご紹介します。

生体直交型クリック反応による汎用性の高い細胞培養足場の作製

複雑な生体組織構造を模倣する生物材料足場の設計は、組織工学や再生医療の進歩にとって極めて重要です。

2次元および3次元細胞培養用生分解性ポリエチレングリコール

ポリエチレングリコールは入手が容易で、簡便に修飾が可能なポリマーであり、組織培養用2次元、3次元の足場をはじめとするヒドロゲルの作製に広く使われています。

Degradable Poly(ethylene glycol) Hydrogels for 2D and 3D Cell Culture

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

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