918075
NanoFabTx™ PLA-nano
for synthesis of 100 and 200 nm particles
Synonym(s):
For nanoparticle synthesis for drug delivery
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About This Item
NACRES:
NA.23
UNSPSC Code:
12161503
Storage temp.:
2-8°C
General description
The NanoFabTx™ Polymer drug formulation kit, PLA, for synthesis of 100 and 200 nm particles is a ready-to-use nanoformulation kit for the synthesis of drug-encapsulating PLA-based nanoparticles. This kit provides properly selected PLA based polymers, stabilizer, and protocols for fabrication of PLA nanoparticles by both nanoprecipitation and microfluidic-based synthesis. The microfluidics protocol uses a NanoFabTx™ device kits (911593, sold separately), which provide all the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).Comprehensive protocols for two different particle synthesis methods are included:
- A nanoprecipitation protocol to prepare drug-encapsulated nanoparticles in standard laboratory glassware.
- A microfluidics protocol using commercial platforms or syringe pumps.
Application
The NanoFabTx™ Polymer drug formulation kit, PLA, for synthesis of 100 and 200 nm particles enables users to encapsulate a wide variety of therapeutic drug molecules in PLA-based nanoparticles. Drug encapsulated nanoparticles synthesized with the NanoFabTx™ kits are suitable for biomedical research applications such as oncology, immuno-oncology, gene delivery, antigen delivery, and vaccine delivery. Poly(D,L-lactic acid) (PLA) is a biocompatible and biodegradable polymer that has been approved by the FDA for biomedical and pharmaceutical applications. Because of their robust mechanical properties and slow degradation, PLA based nanoparticles have been widely used as drug delivery systems to achieve controlled drug release for different types of therapeutic molecules. This kit minimizes laboratory setup with optimized protocols and step-by-step instruction for synthesizing drug-encapsulated nanoparticle-based formulations. It is designed to help pharmaceutical researches achieve reproducible synthesis with high loading efficiencies without the need for lengthy trial-and-error optimization.
Features and Benefits
- Ready-to-use nanoformulation kit for PLA nanoparticles
- Step-by-step protocols developed and tested by our formulation scientists
- Flexible synthesis tool to create uniform and reproducible nanoparticles
- Optimized to make nanoparticles 100–200 nm nanoprecipitation or microfluidics with low polydispersity
- Based on non-toxic, biodegradable polymers
Legal Information
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
Storage Class
11 - Combustible Solids
Regulatory Listings
Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.
918075-1KT: + 918075-BULK: + 918075-VAR: + 918075-1EA:
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Articles
フラッシュナノ沈殿（Flash NanoPrecipitation, FNP）は高充填ナノ粒子を作製する新たな方法として2003年に報告され、物のカプセル化から農薬の送達までさまざまな分野に影響を与えています。
NanoFabTx™プラットフォームは、すぐに使用できる製剤と粒子合成のためのマイクロ流体デバイスにより、薬剤開発を加速させます。
NanoFabTXキットは、mRNAや核酸用の脂質ナノ粒子やリポソームによる正確な薬物送達を可能にします。