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936219

AdQPhos Pd(crotyl)Cl

powder

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About This Item

Empirical Formula (Hill Notation):
C64H66ClFePPd
Molecular Weight:
1063.90
UNSPSC Code:
12352142
NACRES:
NA.21
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Product Name

AdQPhos Pd(crotyl)Cl,

form

powder

Quality Segment

reaction suitability

reaction type: Cross Couplings

greener alternative product characteristics

Catalysis
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color

light red to red, and Pink

functional group

(palladium), phosphine

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SMILES string

Cl[Pd]([P](C12C[C@H]3C[C@H](C[C@H](C3)C2)C1)(C45C[C@H]6C[C@H](C[C@H](C6)C5)C4)c7cccc7)C.CCCC.c8(C9=CC=CC=C9)c(C%10=CC=CC=C%10)c(C%11=CC=CC=C%11)c(C%12=CC=CC=C%12)c8C%13=CC=CC=C%13.[Fe]

General description

The precatalysts derived from AdQPhos exhibit excellent activity towards palladium-catalyzed α-arylation reactions under milder conditions. The strength of these catalytic systems in enabling such reactions were demonstrated with the broad scope of nucleophiles, including nitroalkanes, nitriles, amides, esters, and ketones. Compared to other state-of-the-art catalysts, this system was far superior and served as the first versatile catalytic system to accommodate all these nucleophiles in this context.

Further, by merging with micellar catalysis, this catalytic system demonstrated the feasibility of enabling α-arylation reactions under mild aqueous conditions. This approach provides an environmentally benign alternative to toxic/hazardous solvents like 1,4-dioxane or NMP, bringing modern organic synthesis closer to being ideally sustainable.
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Application

In addition to facilitating α-arylations, these catalysts demonstrate compatibility with various challenging cross-coupling reactions, such as Suzuki-Miyaura, Buchwald-Hartwig aminations, and C-O and C-S cross-couplings.

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

936219-BULK: + 936219-VAR: + 936219-1G:

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