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810205X

Avanti

NBD Sphingosine

Avanti Research™ - A Croda Brand

Synonym(s):

D-erythro-Sphingosine-N-NBD

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About This Item

Empirical Formula (Hill Notation):
C24H39N5O5
CAS Number:
799268-47-6
Molecular Weight:
477.60
MDL number:
MFCD00870345
NACRES:
NA.25
UNSPSC Code:
12352211
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Product Name

NBD Sphingosine, omega(7-nitro-2-1,3-benzoxadiazol-4-yl)(2S,3R,4E)-2-aminooctadec-4-ene-1,3-diol, chloroform:methanol (8:2)

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (810205X-250ug)

manufacturer/tradename

Avanti Research™ - A Croda Brand 810205X

concentration

0.25 mg/mL (810205X-250ug)

shipped in

dry ice

storage temp.

−20°C

General description

Sphingosine is the most bioactive sphingoid with the common long chain base in sphingolipids. It is a constituent of the cell membrane. 7-nitro-2-1,3-benzoxadiazol-4-yl (NBD) sphingosine is a derivative of sphingosine attached with the fluorescent probe, NBD group.

Application

NBD Sphingosine or omega(7-nitro-2-1,3-benzoxadiazol-4-yl)(2S,3R,4E)-2-aminooctadec-4-ene-1,3-diol may be used:
  • as a negative control to determine the binding of Atg12-Atg5 conjugate with phosphatidylethanolamine (PE)-containing liposomes
  • to label sphingosine kinase 1 (SphK1) in order to determine its role in endocytic membrane trafficking
  • to generate 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD)-ceramide C16

Biochem/physiol Actions

Sphingosine serves as a precursor for ceramide. It is involved in the inhibition of protein kinase C in human platelets.

Packaging

5 mL Amber Glass Screw Cap Vial (810205X-250ug)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Disclaimer

Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.

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pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 1 - STOT SE 3

target_organs

Central nervous system

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

>125.5 °F

flash_point_c

> 51.95 °C

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Class I Designated Chemical Substances

prtr

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

810205X-250UG:4.548173352084E12

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