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Merck

840038P

Avanti

12:0 PS

Avanti Research™ - A Croda Brand

Synonym(s):

1,2-didodecanoyl-sn-glycero-3-phospho-L-serine (sodium salt); DLPS; PS(12:0/12:0)

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About This Item

Empirical Formula (Hill Notation):
C30H57NO10PNa
CAS Number:
208757-51-1
Molecular Weight:
645.74
UNSPSC Code:
51191904
NACRES:
NA.25

Key Documents

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Product Name

12:0 PS, 1,2-dilauroyl-sn-glycero-3-phospho-L-serine (sodium salt), powder

SMILES string

[H][C@@](COP([O-])(OC[C@](C([O-])=O)([H])[NH3+])=O)(OC(CCCCCCCCCCC)=O)COC(CCCCCCCCCCC)=O.[Na+]

InChI

1S/C30H58NO10P.Na/c1-3-5-7-9-11-13-15-17-19-21-28(32)38-23-26(24-39-42(36,37)40-25-27(31)30(34)35)41-29(33)22-20-18-16-14-12-10-8-6-4-2;/h26-27H,3-25,31H2,1-2H3,(H,34,35)(H,36,37);/q;+1/p-1/t26-,27+;/m1./s1

InChI key

QBSSGICBQYAHPS-OUPRKWGVSA-M

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 10 mg (840038P-10mg)
pkg of 1 × 200 mg (840038P-200mg)
pkg of 1 × 25 mg (840038P-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 840038P

lipid type

phospholipids

shipped in

dry ice

storage temp.

−20°C

Application

12:0 PS may be used:
  • in the preparation of large unilamellar vesicles (LUVs)
  • as a standard to spike replicas of extracted lipid droplets and calibration curve generation for lipidomic analysis
  • to study its effects on α-secretase activity

Biochem/physiol Actions

Phosphatidylserine (PS) plays a key role in protein kinase C pathways. It also helps in confining the intracellular proteins to membrane leaflets of cytosol.

General description

Phosphatidylserine (PS), an aminophospholipid is negatively charged and accounts for 2–10% of total cellular lipid. It is located in the membrane leaflets.

Packaging

5 mL Amber Glass Screw Cap Vial (840038P-10mg)
5 mL Amber Glass Screw Cap Vial (840038P-200mg)
5 mL Amber Glass Screw Cap Vial (840038P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

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Certificates of Analysis (COA)

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Bao Fu Qiao et al.
The journal of physical chemistry. B, 117(17), 5073-5080 (2013-04-10)
Crystalline vesicles are promising nanomaterials due to their mechanical stability in various environments. To control their fabrication, it is essential to understand the effects of different experimental conditions on crystallization. Here we perform atomistic molecular dynamics simulations of anionic lipid
Kristof Schutters et al.
Apoptosis : an international journal on programmed cell death, 15(9), 1072-1082 (2010-05-05)
Cells are able to execute apoptosis by activating series of specific biochemical reactions. One of the most prominent characteristics of cell death is the externalization of phosphatidylserine (PS), which in healthy cells resides predominantly in the inner leaflet of the
Marcus O W Grimm et al.
International journal of molecular sciences, 14(3), 5879-5898 (2013-03-15)
Alzheimer's disease (AD) is characterized by extracellular accumulation of amyloid-β peptide (Aβ), generated by proteolytic processing of the amyloid precursor protein (APP) by β- and γ-secretase. Aβ generation is inhibited when the initial ectodomain shedding is caused by α-secretase, cleaving
Jung Yong Eum et al.
Journal of chromatography. A, 460849-460849 (2020-01-14)
Aging refers to the intracellular accumulation of reactive oxygen species that damages proteins, DNA, and lipids. As alterations in lipid metabolism may trigger metabolic disorders and the onset of metabolic diseases, changes in lipid profiles can be closely related to
Anik Forest et al.
Journal of proteome research, 17(11), 3657-3670 (2018-09-27)
The goal of this work was to develop a label-free, comprehensive, and reproducible high-resolution liquid chromatography-mass spectrometry (LC-MS)-based untargeted lipidomic workflow using a single instrument, which could be applied to biomarker discovery in both basic and clinical studies. For this
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