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About This Item
Empirical Formula (Hill Notation):
C48H96NO8P
CAS Number:
Molecular Weight:
846.25
MDL number:
NACRES:
NA.25
UNSPSC Code:
51191904
Product Name
4ME 16:0 PC, Avanti Research™ - A Croda Brand
description
1,2-diphytanoyl-sn-glycero-3-phosphocholine, chloroform
assay
>99% (TLC)
form
liquid
packaging
pkg of 1 × 2.5 mL (850356C-25mg)
pkg of 1 × 20 mL (850356C-500mg)
pkg of 2 × 4 mL (850356C-200mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
concentration
10 mg/mL (850356C-25mg)
25 mg/mL (850356C-200mg)
25 mg/mL (850356C-500mg)
shipped in
dry ice
storage temp.
−20°C
Application
4ME 16:0 PC is suitable for use:
- to study its phase behaviour and its interactions with the representative antimicrobial peptide PGLa from Xenopus laevis (peptidyl-glycylleucine-carboxyamide
- to improve the mechanical stability of planar lipid bilayer membrane
- to prepare giant unilamellar vesicles (GUVs)
Biochem/physiol Actions
4ME 16:0 PC/DPhPC (1,2-diphytanoyl-sn-glycero-3-phosphocholine can be used as a bilayer mimic for electrophysiological measurements. It is stable under mechanical stress but the ester linkages are liable to hydrolysis under acidic or alkaline conditions.
General description
4ME 16:0 PC/DPhPC (1,2-diphytanoyl-sn-glycero-3-phosphocholine is a synthetic lipid. It has ester linkages between acyl chains and glycerol backbone and also between the headgroup and glycerol backbone. This neutral lipids possess high steric asymmetry. It remains in fluid or viscous liquid crystalline state over a wide range of temperature.
Lipids containing diphytanoyl fatty acid chains have been used to produce stable planar lipid membranes (see References). Diphytanoyl phosphatidylcholine does not exhibit a detectable gel to liquid crystalline phase transition from -120°C to +120°C.The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products from oxidization and hydrolysis.
Packaging
30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (850356C-500mg)
5 mL Clear Glass Sealed Ampule (850356C-200mg)
5 mL Clear Glass Sealed Ampule (850356C-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
signalword
Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
target_organs
Central nervous system, Liver,Kidney
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Formation and characterization of planar lipid bilayer membranes from synthetic phytanyl-chained glycolipids
Baba T, et al.
Biochimica et Biophysica Acta - Biomembranes, 1421(1), 91-102 (1999)
Physical properties of bilayer membranes formed from a synthetic saturated phospholipid in n-decane.
W R Redwood et al.
Biochimica et biophysica acta, 233(1), 1-6 (1971-03-09)
Chan Cao et al.
Nature communications, 10(1), 4918-4918 (2019-10-31)
Nanopore sensing is a powerful single-molecule approach for the detection of biomolecules. Recent studies have demonstrated that aerolysin is a promising candidate to improve the accuracy of DNA sequencing and to develop novel single-molecule proteomic strategies. However, the structure-function relationship
Stephanie Tristram-Nagle et al.
Chemistry and physics of lipids, 163(6), 630-637 (2010-05-08)
Diphytanoylphosphatidylcholine (DPhyPC) is a branched chain lipid often used for model membrane studies, including peptide/lipid interactions, ion channels and lipid rafts. This work reports results of volume measurements, water permeability measurements P(f), X-ray scattering from oriented samples, and X-ray and
Tim Diederichs et al.
Nature communications, 10(1), 5018-5018 (2019-11-07)
Nanopores are key in portable sequencing and research given their ability to transport elongated DNA or small bioactive molecules through narrow transmembrane channels. Transport of folded proteins could lead to similar scientific and technological benefits. Yet this has not been
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