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Merck

860510P

Avanti

C10 Ceramide (d18:1/10:0)

Avanti Research™ - A Croda Brand

Synonym(s):

N-decanoyl-D-erythro-sphingosine

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About This Item

Empirical Formula (Hill Notation):
C28H55NO3
CAS Number:
111122-57-7
Molecular Weight:
453.74
MDL number:
MFCD02259134
UNSPSC Code:
12352211
NACRES:
NA.25

Key Documents

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Product Name

C10 Ceramide (d18:1/10:0), Avanti Research™ - A Croda Brand 860510P, powder

SMILES string

OC[C@]([H])(NC(CCCCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC

InChI

1S/C28H55NO3/c1-3-5-7-9-11-12-13-14-15-16-18-19-21-23-27(31)26(25-30)29-28(32)24-22-20-17-10-8-6-4-2/h21,23,26-27,30-31H,3-20,22,24-25H2,1-2H3,(H,29,32)/b23-21+/t26-,27+/m0/s1

InChI key

FDWVAQFAMZLCAX-NBNLIBPQSA-N

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 5 mg (860510P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 860510P

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

Application

C10 Ceramide (d18:1/10:0) or N-decanoyl-D-erythro-sphingosine has been used:
  • as an internal standard in galactocerebrosidase (GALC) assay
  • to study its role on the physical properties of edible organogels and on their ability to induce cell death of various cancer cell lines
  • to study its mixing behavior with other ceramides having the same sphingosine base but varying N-linked acyl chain length

Biochem/physiol Actions

Ceramides modulate stress responses and inflammation. It also controls cell differentiation, proliferation and apoptosis.

General description

C10 Ceramide (d18:1/10:0) is a synthetic ceramide containing sphingosine with decanoic acid. It has a short acyl chain length than sphingosine acyl chain.

Packaging

5 mL Amber Glass Screw Cap Vial (860510P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Meenu N Perera et al.
Chemistry and physics of lipids, 194, 110-116 (2015-09-27)
A ceramide commonly found in mammalian cells, C16-ceramide (N-palmitoyl-d-erythro-sphingosine), is capable of forming large, protein-permeable channels in the mitochondrial outer membrane (MOM). However, C16-ceramide is unable to permeabilize the plasma membrane of erythrocytes. This specificity is unexpected considering that ceramide
Zhixing Wang et al.
The Journal of investigative dermatology, 133(3), 668-676 (2012-10-26)
The stratum corneum is composed of protein-enriched corneocytes embedded in an intercellular matrix of nonpolar lipids organized as lamellar layers and giving rise to epidermal permeability barrier (EPB). EPB defects have an important role in the pathophysiology of skin diseases

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