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860677P

Avanti

C18 Ceramide-d7 (d18:1-d7/18:0)

Avanti Research™ - A Croda Brand

Synonym(s):

N-stearoyl-D-erythro-sphingosine (d7)

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About This Item

Empirical Formula (Hill Notation):
C36H64D7NO3
CAS Number:
1840942-14-4
Molecular Weight:
573.00
MDL number:
MFCD34647483
UNSPSC Code:
12352100
NACRES:
NA.25
Assay:
>99% (TLC)
Form:
powder
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Product Name

C18 Ceramide-d7 (d18:1-d7/18:0), Avanti Research™ - A Croda Brand 860677P, powder

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (860677P-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 860677P

shipped in

dry ice

storage temp.

−20°C

SMILES string

OC[C@]([H])(NC(CCCCCCCCCCCCCCCCC)=O)[C@@](O)([H])/C=C/CCCCCCCCCCC(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H]

InChI

1S/C36H71NO3/c1-3-5-7-9-11-13-15-17-18-20-22-24-26-28-30-32-36(40)37-34(33-38)35(39)31-29-27-25-23-21-19-16-14-12-10-8-6-4-2/h29,31,34-35,38-39H,3-28,30,32-33H2,1-2H3,(H,37,40)/b31-29+/t34-,35+/m0/s1/i2D3,4D2,6D2

InChI key

VODZWWMEJITOND-MUVBWDEFSA-N

General description

C18 Ceramide (d18:1/18:0) is a synthetic ceramide containing sphingosine with stearic acid. C18 Ceramide-d7 (d18:1-d7/18:0) is a deuterated derivative of ceramide d18:1/18:0.

Application

C18 Ceramide-d7 (d18:1-d7/18:0) has been used as a standard in liquid chromatography–mass spectrometry (LC-MS) for quantitative analysis of C18 ceramide in skeletal muscle. It has also been used as a standard to measure C35–C39 ceramides in zebrafish brain and human embryonic kidney cell line (HEK293) by thermo q-exactive plus quadrupole-orbitrap mass spectrometery.

Biochem/physiol Actions

C18 ceramide is involved in cell growth inhibition. Determining the levels of the ceramides (Cer) d18:1/16:0, Cer d18:1/18:0, Cer d18:1/24:0, and Cer d18:1/24:1 and ratios in human plasma enables the prognosis of fatal outcome of coronary artery disease. Stable isotope form of C18 ceramide d18:1/18:0 supports a newly described validated liquid chromatography-tandem mass spectrometry methodology for their clinical-scaled measurement.

Packaging

5 mL Amber Glass Screw Cap Vial (860677P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

flash_point_f

No data available

flash_point_c

No data available

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

860677P-VAR: + 860677P-BULK: + 860677P-1MG:

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Takhar Kasumov et al.
Analytical biochemistry, 401(1), 154-161 (2010-02-25)
We present an optimized and validated liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) method for the simultaneous measurement of concentrations of different ceramide species in biological samples. The method of analysis of tissue samples is based on Bligh and
Dimple Kauhanen et al.
Analytical and bioanalytical chemistry, 408(13), 3475-3483 (2016-02-29)
Monitoring the levels of the ceramides (Cer) d18:1/16:0, Cer d18:1/18:0, Cer d18:1/24:0, and Cer d18:1/24:1 and ratios thereof in human plasma empowers the prediction of fatal outcome of coronary artery disease (CAD). We describe a validated liquid chromatography-tandem mass spectrometry
Tejia Zhang et al.
Scientific reports, 9(1), 19939-19939 (2019-12-29)
Extensive characterisations of the zebrafish genome and proteome have established a foundation for the use of the zebrafish as a model organism; however, characterisation of the zebrafish lipidome has not been as comprehensive. In an effort to expand current knowledge
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