03-0145-00

SMC^® Amyloid Beta 1-40 High Sensitivity Immunoassay Kit

Name: SMC<SUP>®</SUP> Amyloid Beta 1-40 High Sensitivity Immunoassay Kit
Brand: MM

Used for ultrasensitive quantification of Amyloid Beta 1-40 (Aβ40) in human, rat or mouse plasma or cerebrospinal fluid (CSF)

Synonym(s):

Abeta 1-40 immunoassay kit, Abeta 40 Single Molecule Counting kit, Abeta 40 immunoassay kit, Abeta 40 ultra-sensitive immunoassay

Select a Size

About This Item

UNSPSC Code:

12161503

eCl@ss:

32161000

NACRES:

NA.84

Key Documents

View All Documentation

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Quality Level

200

usage

kit sufficient for 96 wells

species reactivity

human

manufacturer/tradename

SMC^®

assay range

sensitivity: 5.86 pg/mL
(lower limit of quantification)

technique(s)

single molecule counting: suitable

input

plasma (K2 EDTA)
cerebrospinal fluid (CSF)

UniProt accession no.

P05067

compatibility

for use with FemtoQuest^™ and SMCxPRO^® instruments

shipped in

wet ice

Related Categories

AAW™ Automated Assay Workstation

Immunoassay Platform Solutions

Lab Automation

Protein Biology

SMC^® High Sensitivity Immunoassay Kits

General description

Amyloid Beta 1-40 (Aβ1-40) is a peptide that arises from the proteolytic cleavage of the amyloid precursor protein (APP), a transmembrane protein thought to be involved in neuronal development and function. Aβ1-40 is one of the most common isoforms generated from APP, alongside Aβ1-42, which is more toxic and associated with the formation of amyloid plaques in neurodegenerative diseases.
Aβ1-40 plays a significant role in the pathophysiology of Alzheimer′s disease. Elevated levels of Aβ1-40 in the brain can contribute to neuroinflammation and neuronal damage, disrupting cell signaling and promoting the formation of amyloid plaques. These plaques are characteristic of AD and are believed to trigger a cascade of neurodegenerative processes, leading to cognitive decline and other symptoms associated with the disease. Understanding the function and implications of Aβ1-40 is essential for developing effective diagnostic tools and therapeutic strategies aimed at mitigating its harmful effects in neurodegenerative conditions.

Application

Neuroscience/Neurological Disorders/Signaling

Biochem/physiol Actions

Although Amyloid Beta 40 was detectable in mouse and rat samples, the assay has not been verified for these species.

Features and Benefits

Exceptional Sensitivity: Detects Amyloid Beta 1-40 at femtogram levels, significantly outperforming conventional ELISA methods.
Wider Dynamic Range: Minimizes background interference to deliver clearer signals and improved assay reliability.
Optimized Workflow Efficiency: Automation-compatible reagents streamline lab processes and reduce manual intervention.
Experienced Technical Support: Supported by skilled field scientists and technical teams with expertise in SMC^® assays.

Packaging

96 well assay

Analysis Note

Sensitivity: LLOQ 5,860 fg/mL* (SMCxPRO^® instrument
Standard Curve Range: 340-350,000 fg/mL
Intra-assay CV: <15%
Inter-assay CV: <10%
Linearity: Plasma: 104% CSF: 109%
Recovery: Plasma 110% CSF: 100%

*Indicative LLOQ created from average of 14 independent in house runs, where >80% met same value defined with CV & Recovery +/- 20%. Refer to CoA for lot specific performance.

Neuroscience Neurological Disorders Neurodegenerative Diseases Alzheimer′s Disease

Legal Information

FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany

SMC is a registered trademark of Singulex

SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Pictograms

GHS06,GHS08

Signal Word

Danger

Hazard Statements

H302 + H332,H311,H319,H360FD,H412

Precautionary Statements

P273 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.