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Merck

100065

2-APB

≥97% (titration), crystalline solid, Ins(1,4,5)P3-induced Ca2+ release inhibitor, Calbiochem®

Synonym(s):

2-APB, 2-Aminoethoxydiphenylborate, (2-Aminoethoxy)diphenylborane

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About This Item

Empirical Formula (Hill Notation):
C14H16BNO
CAS Number:
524-95-8
Molecular Weight:
225.09
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00014823
Assay:
≥97% (titration)
Form:
crystalline solid
Quality level:
100
Storage condition:
OK to freeze, desiccated (hygroscopic)

Key Documents

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Product Name

2-APB, A cell-permeable modulator of Ins(1,4,5)P3-induced Ca2+ release.

SMILES string

B(OCCN)(c2ccccc2)c1ccccc1

InChI

1S/C14H16BNO/c16-11-12-17-15(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10H,11-12,16H2

InChI key

BLZVCIGGICSWIG-UHFFFAOYSA-N

description

Drug Control: Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet, RTECS - ED6150000

assay

≥97% (titration)

form

crystalline solid

manufacturer/tradename

Calbiochem®

drug control

Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet

storage condition

OK to freeze, desiccated (hygroscopic)

color

white

solubility

DMSO: 20 mg/mL, 95% ethanol: 25 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Ins(1,4,5)P3-induced Ca2+ release
Product does not compete with ATP.
Reversible: no
Target IC50: 42 µM against Ins(1,4,5)P3-induced Ca2+ release from rat cerebellar microsomal preparations

Disclaimer

Toxicity: Standard Handling (A)

General description

A cell-permeable modulator of Ins(1,4,5)P3-induced Ca2+ release. Inhibits Ins(1,4,5)P3-induced Ca2+ release from rat cerebellar microsomal preparations (IC50 = 42 µM) without affecting [3H]-Ins(1,4,5)P3 binding to its receptor. In liver cells, 2-APB inhibits store-operated Ca2+ channels through a mechanism which may involve its binding to either the channel protein or an associated regulatory protein. Has no effect on the Ca2+ release from the ryanodine-sensitive Ca2+ store prepared from rat leg skeletal muscle and heart.

Other Notes

Brooke, R. T., et al. 2004. Lab. Invest.84, 29.
Gregory, R.B., et al. 2001. Biochem. J.354, 285.
Ma, H.T., et al. 2001. J. Biol. Chem.276, 18888.
Ascher-Landsberg, S., et al. 1999. Biochem. Biophys. Res. Commun.264, 979.
Maruyama, T., et al. 1997. J. Biochem.122, 498.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Class I Designated Chemical Substances

prtr

100065-MG: + 100065-100MG: + 100065-1.1ML:

jan

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Global Trade Item Number

SKUGTIN
100065-100MGCN07790788056766

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