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Merck

1.00289

L-Glutamine

for biochemistry

Synonym(s):

L-Glutamic acid-5-amide, Gln, (S)-2,5-Diamino-5-oxopentanoic acid, L-Glutamic acid 5-amide, Levoglutamide

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About This Item

Linear Formula:
H2NCOCH2CH2CH(NH2)CO2H
CAS Number:
56-85-9
Molecular Weight:
146.14
NACRES:
NA.21
EC Index Number:
200-292-1
UNSPSC Code:
12352209
Beilstein/REAXYS Number:
1723797

Key Documents

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Product Name

L-Glutamine, for biochemistry

InChI

1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1

SMILES string

N[C@@H](CCC(N)=O)C(O)=O

InChI key

ZDXPYRJPNDTMRX-VKHMYHEASA-N

form

solid

potency

7500 mg/kg LD50, oral (Rat)

pH

4.0-6.0 (20 °C, 25 g/L in H2O)

mp

185 °C (dec.) (lit.)

solubility

100 g/L

density

1.47 g/cm3 at 20 °C

bulk density

640 kg/m3

storage temp.

2-30°C

Quality Level

100

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Analysis Note

Assay (perchloric acid titration, calculated on dried substance): 99.0 - 101.0 %
Identity (IR-spectrum): passes test
Appearance: white to almost white, fine powder
Appearance of solution (25 g/l; CO₂-free water): clear and colorless
Spec. rotation (α 20/D, 100 g/l, hydrochloric acid 2 mol/l, calc. on dried substance): +31,5 to +33,0
Chloride (Cl): ≤ 200 ppm
Sulfate (SO₄): ≤ 200 ppm
Heavy metals (as Pb): ≤ 10 ppm
As (Arsenic): ≤ 5 ppm
Ca (Calcium): ≤ 10 ppm
Co (Cobalt): ≤ 5 ppm
Fe (Iron): ≤ 5 ppm
K (Potassium): ≤ 5 ppm
Mg (Magnesium): ≤ 5 ppm
Na (Sodium): ≤ 50 ppm
Zn (Zinc): ≤ 5 ppm
Ninhydrin-positive substances (LC)(any ninhydrin-positive impurity): ≤ 0.3 %
Ninhydrin-positive substances (LC) (ammonium (570 nm)): ≤ 0.1 %
Ninhydrin-positive substances (LC)(total impurities): ≤ 0.5 %
Loss on drying (105 °C; 3 h): ≤ 0.3 %

Application


  • Low-protein diet supplemented with 1% L-glutamine improves growth performance, serum biochemistry, redox status, plasma amino acids, and alters fecal microbiota in weaned piglets.: This study demonstrates how L-glutamine supplementation in a low-protein diet can significantly enhance growth metrics and overall health in weaned piglets (Li et al., 2024).

  • Functionalization of β-cyclodextrin metal-organic frameworks with gelatin and glutamine for drug delivery of curcumin to cancerous cells.: This article covers the development of a novel drug delivery system using glutamine-modified frameworks for targeted cancer therapy (Sadeh et al., 2024).

Biochem/physiol Actions

L-Glutamine is an essential amino acid that is a crucial component of culture media that serves as a major energy source for cells in culture. L-Glutamine is very stable as a dry powder and as a frozen solution. In liquid media or stock solutions, however, L-glutamine degrades relatively rapidly. Optimal cell performance usually requires supplementation of the media with L-glutamine prior to use.

Storage Class

13 - Non Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Global Trade Item Number

SKUGTIN
1.00289.100004022536003955
1.00289.901004022536692586

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