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1.00574

NMP

for Peptide Synthesis

Synonym(s):

1-Methyl-2-pyrrolidone, NMP, N-Methyl-2-pyrrolidone

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About This Item

Empirical Formula (Hill Notation):
C5H9NO
CAS Number:
872-50-4
Molecular Weight:
99.13
UNSPSC Code:
12352115
EC Index Number:
212-828-1
NACRES:
NA.22
MDL number:
MFCD00003193
Assay:
≥99.7% (GC)
Bp:
202 °C/1013 hPa
Vapor pressure:
0.32 hPa ( 20 °C)
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Product Name

1-Methyl-2-pyrrolidone, for Peptide Synthesis

Quality Segment

200

vapor pressure

0.32 hPa ( 20 °C)

assay

≥99.7% (GC)

form

liquid

autoignition temp.

245 °C

potency

3598 mg/kg LD50, oral (Rat), 8000 mg/kg LD50, skin (Rabbit)

expl. lim.

1.3-9.5 % (v/v)

dilution

(for synthesis)

pH

8.5-10.0 (20 °C, 100 g/L in H2O)

bp

202 °C/1013 hPa

mp

-24 °C

transition temp

flash point 91 °C

density

1.03 g/cm3 at 20 °C

application(s)

peptide synthesis

storage temp.

2-30°C

SMILES string

N1(CCCC1=O)C

InChI

1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3

InChI key

SECXISVLQFMRJM-UHFFFAOYSA-N

General description

N-methyl-2-pyrrolidone (NMP) is an organic solvent that finds applications in numerous industries, including petrochemicals, plastics, microelectronics, and to produce pigments, cosmetics, and drugs. It is commonly used worldwide as an organic solvent, intermediate, or surfactant in various industrial and consumer applications. The unique characteristics of NMP, including its ability to mix with water and organic solvents, and its temperature, polarity, and composition stability, make it a solvent of great interest in extractive distillation.

Application

1-Methyl-2-pyrrolidone can be used as a solvent during the peptide bond formation reactions.

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Danger

Hazard Classifications

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

wgk

WGK 1

flash_point_f

195.8 °F - Pensky-Martens closed cup

flash_point_c

91 °C - Pensky-Martens closed cup

pictograms

Health hazardExclamation mark
GHS08,GHS07

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

Class I Designated Chemical Substances

prtr

Group 4: Flammable liquids + Type 3 petroleums + Hazardous rank III + Water soluble liquid

fsl

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