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Merck

1.05980

D-Mannitol

EMPROVE® ESSENTIAL, Ph. Eur., BP, ChP, JP, USP, FCC, E 421

Synonym(s):

Mannite

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About This Item

Empirical Formula (Hill Notation):
C6H14O6
CAS Number:
69-65-8
Molecular Weight:
182.17
UNSPSC Code:
12352201
EC Index Number:
200-711-8
E Number:
E421
MDL number:
MFCD00064287
Beilstein/REAXYS Number:
1721898

Key Documents

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Product Name

D-Mannitol, EMPROVE® ESSENTIAL, Ph. Eur., BP, ChP, JP, USP, FCC, E 421

SMILES string

OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

InChI key

FBPFZTCFMRRESA-KVTDHHQDSA-N

InChI

1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1

agency

BP
ChP
JP
Ph. Eur.
USP

reg. compliance

FCC

product line

EMPROVE® ESSENTIAL

form

fine powder

autoignition temp.

410 °C

potency

13500 mg/kg LD50, oral (Rat)

quality

E 421

particle size

(see specification)

pH

5-7 (20 °C, 100 g/L in H2O)

bp

290-295 °C/4 hPa

mp

167-170 °C (lit.)

solubility

213 g/L

application(s)

liquid formulation
pharmaceutical
semi-solid formulation
solid formulation

storage temp.

2-25°C

Quality Level

500

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Application

Mannitol is widely used in pharmaceutical formulations and food applications, mainly as diluent and bulking agent in solid oral formulations such as tablets. For mannitols with DC properties or for a product specifically developed for wet granulation, please explore the Parteck® range of products.

Biochem/physiol Actions

A sugar alcohol sweet tastant. Used in sweetness inhibition studies.

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our EMPROVE® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
PARTECK is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

Certificates of Analysis (COA)

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Global Trade Item Number

SKUGTIN
1.05980.250004022536961378
1.05980.902404022536994086

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