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Merck

108976

Leupeptin, Hemisulfate, Synthetic

Synthetic version of the microbial-derived inhibitor Leupeptin against trypsin-like and cysteine protease activities.

Synonym(s):

Leupeptin, Hemisulfate, Synthetic, Ac-LLR-CHO, 1/2H2SO4

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About This Item

Empirical Formula (Hill Notation):
C20H38N6O4 · 0.5H2SO4
CAS Number:
103476-89-7
Molecular Weight:
475.59
UNSPSC Code:
12352202
NACRES:
NA.21
MDL number:
MFCD00037012
Assay:
≥95% (sum of isomers, HPLC)
Form:
solid
Quality level:
200
Storage condition:
OK to freeze, desiccated (hygroscopic)

Key Documents

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SMILES string

[N+H](=C(N)N)CCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CC(C)C)CC(C)C)C=O

InChI

1S/C20H38N6O4/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23)/p+1/t15-,16-,17-/m0/s1

InChI key

GDBQQVLCIARPGH-ULQDDVLXSA-O

description

Merck USA index - 14, 5456.

assay

≥95% (sum of isomers, HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic)

color

off-white

solubility

water: 50 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

200

Disclaimer

Toxicity: Standard Handling (A)

General description

Synthetic version of the microbial-derived inhibitor Leupeptin (Cat. No. 108975 ) against trypsin-like and cysteine protease activities.

Other Notes

Ac-Leu-Leu-arginal, hemisulfate

Packaging

Packaged under inert gas

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

108976-MG: + 108976-25MG: + 108976E-50GM: + 108976E-10GM: + 108976E-50RGM: + 108976-10GM: + 108976E-GM: + 108976-0GM: + 108976-10MG: + 108976E-250GM:

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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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S Joseph Endicott et al.
The Journal of cell biology, 219(12) (2020-10-14)
Chaperone-mediated autophagy (CMA) is the most selective form of lysosomal proteolysis, where individual peptides, recognized by a consensus motif, are translocated directly across the lysosomal membrane. CMA regulates the abundance of many disease-related proteins, with causative roles in neoplasia, neurodegeneration
Pietri Puustinen et al.
Autophagy, 16(10), 1871-1888 (2020-01-28)
Macroautophagy/autophagy is a central component of the cytoprotective cellular stress response. To enlighten stress-induced autophagy signaling, we screened a human kinome siRNA library for regulators of autophagic flux in MCF7 human breast carcinoma cells and identified the catalytic subunit of

Global Trade Item Number

SKUGTIN
108976-25MGCN04055977208610
108976-10MGCN07790788056285

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