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Merck

137119

Phospho-L-Tyrosine Disodium Salt

EMPROVE® EXPERT

Synonym(s):

Phospho-L-tyrosine disodium salt, PTyr, Phospho-Tyrosine, Phosphotyrosine

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About This Item

Empirical Formula (Hill Notation):
C9H10NNa2O6P
CAS Number:
Molecular Weight:
305.13
MDL number:
UNSPSC Code:
12352209
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Quality Level

biological source

synthetic

product line

EMPROVE® EXPERT

form

powder or crystals

packaging

pkg of 1 kg (in PE drum, 2 inner PE liners 1371191000), pkg of 10 kg (in PE drum, 2 inner PE liners 1371199010), pkg of 100 g (in PE tub, inner glas bottle 1371190100)

pH

5.5-9.0 (10 g/L in H2O)

solubility

25 g/L, ≤70 g/L (in complex feed)

suitability

suitable for manufacturing use (cell culture)

storage temp.

2-8°C

SMILES string

[Na].[Na].[P](=O)(Oc1ccc(cc1)C[C@H](N)C(=O)O)(O)O

InChI

1S/C9H12NO6P.2Na/c10-8(9(11)12)5-6-1-3-7(4-2-6)16-17(13,14)15;;/h1-4,8H,5,10H2,(H,11,12)(H2,13,14,15);;/t8-;;/m0../s1

InChI key

JRFJYPIBECDABY-JZGIKJSDSA-N

General description

Modified amino acids are inhouse manufactured amino acid derivatives with specific properties enabling the intensification of cell culture processes.

Together with the companion product Sulfo-Cysteine sodium salt, the new modified amino acid Phospho-Tyrosine disodium salt can be used as replacement for tyrosine to generate highly concentrated, neutral pH feeds. Both modified amino acids eliminate the need for alkaline feeds, which are normally applied to ensure solubility and stability of the unmodified amino acids tyrosine and cysteine.
Our SAFC® portfolio of high-quality products for biopharmaceutical processing withstands strict quality control procedures and is produced according to MQ-500 requirements as defined by the M-Clarity program.

M-Clarity Program

As part of our EMPROVE® Program, our raw materials are offered with EMPROVE® Dossiers which provide comprehensive, up-to-date documentation to help you navigate regulatory challenges, manage risks, and improve your manufacturing processes.

Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.

Features and Benefits

  • Reduced complexity in fed-batch process
  • High concentrations of modified tyrosine in main feeds at neutral pH
  • Enhanced solubility up to 70g/l in complex feed
  • Prevention of caustic shocks in the bioreactor due to high pH feeds
  • More convenient preparation process with less contamination risks
  • Higher feed stability at room temperature

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany


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Storage Class

11 - Combustible Solids

wgk

WGK 3


Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

1371190100:4548173353494 + 1371199010:4548173353517 + 1371191000:4548173353500 + 137119-BULK: + 1371190000:

jan



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