Skip to Content
Merck

Key Documents

View All Documentation

1.37136

Tetrahydrofuran

EMPROVE® ESSENTIAL

Synonym(s):

Tetrahydrofuran, Butylene oxide, Oxolane, Tetramethylene oxide

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):
C4H8O
CAS Number:
109-99-9
Molecular Weight:
72.11
UNSPSC Code:
12352005
Beilstein/REAXYS Number:
102391
MDL number:
MFCD00005356
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Level

500

vapor pressure

114 mmHg ( 15 °C), 143 mmHg ( 20 °C)

product line

EMPROVE® ESSENTIAL

assay

≥99.8% (GC)

form

liquid

autoignition temp.

610 °F

expl. lim.

1.8-11.8 %

technique(s)

API processing | polymorph screening: suitable

pH

7-8 (20 °C, 200 g/L in H2O)

mp

−108 °C (lit.)

density

0.889 g/mL at 25 °C (lit.)

application(s)

pharmaceutical

storage temp.

2-25°C

General description

We offer a range of high quality critical raw materials, solvents and reagents plus the documentation and expertise to meet stringent regulatory requirements. In addition to our comprehensive portfolio, we also offer custom manufacturing services to meet your exact needs. As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Tetrahydrofuran is a versatile organic solvent for API synthesis, as a pre-cursor to polymers and it is used for several extended applications during drug manufacturing. The performance of the processes increases with the usage of Tetrahydrofuran in certain API′s than other available solvents. Tetrahydrofuran Emprove® Essential is manufactured according to GMP guidelines and is suitable for pharmaceutical applications.

Other Notes

Emprove Documentation

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Still not finding the right product?

Explore all of our products under Tetrahydrofuran

signalword

Danger

supp_hazards

EUH019

Storage Class

3 - Flammable liquids

wgk

WGK 1

flash_point_f

-6.2 °F - closed cup

flash_point_c

-21.2 °C - closed cup

target_organs

Central nervous system, Respiratory system

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

Class I Designated Chemical Substances

prtr

1371360000: + 1371369025: + 1371369200: + 1371361000:

jan

Group 4: Flammable liquids + Type 1 petroleums + Hazardous rank II + Water soluble liquid

fsl

Stay compliant with GMP using the Emprove® Program

Accelerate qualification, maintain compliance, and save time with Emprove® Dossiers.

Download Dossiers

Note: you will be brought to EmproveSuite.com. Your username and password are separate from SigmaAldrich.com and may differ.

Register for free and access Emprove® Dossiers within minutes. Upgrade your subscription plan to unlock advanced and customized content in the Emprove® Suite

Not finding what you are looking for? Visit the Emprove® Program Help page.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Global Trade Item Number

SKUGTIN
1.37136.100004054839663833
1.37136.902504054839663840
1.37136.920004054839663857