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Merck

171601

Amyloid Precursor Protein β-Secretase Inhibitor

The Amyloid Precursor Protein β-Secretase Inhibitor controls the biological activity of Amyloid Precursor Protein β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

Synonym(s):

Amyloid Precursor Protein β-Secretase Inhibitor, KTEETSEVN(stat)VAEF

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About This Item

Empirical Formula (Hill Notation):
C73H118N16O27
Molecular Weight:
1651.81
NACRES:
NA.77
UNSPSC Code:
12352202
Assay:
≥98% (HPLC)
Form:
lyophilized
Quality level:
100
Storage condition:
OK to freeze, desiccated (hygroscopic)

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assay

≥98% (HPLC)

form

lyophilized

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic)

solubility

aqueous buffer, pH 7.5: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

Cell permeable: no
Primary Target
APP
Product does not compete with ATP.
Reversible: no
Target IC50: 30 nM against amyloid precursor protein (APP) β-secretase

Disclaimer

Toxicity: Standard Handling (A)

General description

A potent inhibitor of the amyloid precursor protein (APP) β-secretase (IC50 = 30 nM).

Other Notes

H-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Stat-Val-Ala-Glu-Phe-OH [Stat = (3S,4S)-Statine]
Sinha, S., et al. 1999. Nature 402, 537.

Physical form

Supplied as a trifluoroacetate salt.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

171601-500UG: + 171601-UG:

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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Zhi-Hao Wang et al.
Progress in neurobiology, 202, 102032-102032 (2021-03-16)
ApoE4, an apolipoprotein implicated in cholesterol transport and amyloid-β (Aβ) metabolism, is a major genetic risk determinant for Alzheimer's Disease (AD) and drives its pathogenesis via Aβ-dependent and -independent pathways. C/EBPβ, a proinflammatory cytokines-activated transcription factor, is upregulated in AD

Global Trade Item Number

SKUGTIN
171601-500UGCN04055977207293

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