218705
Casein Kinase I Inhibitor, D4476
InSolution, ≥95%
Synonym(s):
InSolution Casein Kinase I Inhibitor, D4476
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About This Item
Empirical Formula (Hill Notation):
C23H18N4O3
Molecular Weight:
398.41
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
liquid
Quality level:
Storage condition:
OK to freeze
desiccated (hygroscopic)
protect from light
desiccated (hygroscopic)
protect from light
Product Name
Casein Kinase I Inhibitor, D4476, InSolution, ≥95%
assay
≥95% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
shipped in
wet ice
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Cell permeable: yes
Primary Target
CK1, CK1d
CK1, CK1d
Product competes with ATP.
Reversible: no
Target IC50: 0.2 µM, 0.3 µM against CK1, CK1d, respectively
Disclaimer
Toxicity: Irritant (B)
General description
A cell-permeable, potent, and relatively specific ATP-competitive inhibitor of CK1 (IC50 = 200 nM from S. pombe; 0.3 µM for CK1δ) and ALK5 (IC50 = 500 nM). A weak inhibitor of p38α MAP kinase (IC50 = 12 µM) and several other kinases tested, including PKB, SGK, and GSK-3β. Suppresses the site-specific phosphorylation (Ser322 and Ser325) and nuclear exclusion of FOXO1A in H4IIE hepatoma cells. Shown to be ~10-fold more potent than IC261 (Cat. No. 400090; IC50 = 2.5 µM for CK1).
Other Notes
Rena, G., et al. 2004. EMBO Reports5, 60.
Packaging
Packaged under inert gas
Please refer to vial label for lot-specific concentration.
Physical form
A 10 mM (1 mg/251 µl) solution of Casein Kinase I Inhibitor, D4476 (Cat. No. 218696) in DMSO
Preparation Note
Following initial use, aliquot and refrigerate (4°C).
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Certificates of Analysis (COA)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 218705-1MGCN | 04055977202540 |
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