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Merck

235135

Corticosterone

≥95% (HPLC), crystalline powder, corticosteroid hormone, Calbiochem

Synonym(s):

Corticosterone, (11β)-11,21-Dihydroxypregn-4-ene-3,20-dione, Reichstein’s substance H

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About This Item

Empirical Formula (Hill Notation):
C21H30O4
CAS Number:
50-22-6
Molecular Weight:
346.46
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00037715
Assay:
≥95% (HPLC)
Form:
crystalline powder
Quality level:
100
Storage condition:
OK to freeze

Key Documents

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Product Name

Corticosterone, Corticosteroid hormone synthesized in response to stress.

SMILES string

O[C@@H]1[C@H]2[C@H]([C@H]4[C@@]([C@H](CC4)C(=O)CO)(C1)C)CCC3=CC(=O)CC[C@@]32C

InChI

1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1

InChI key

OMFXVFTZEKFJBZ-HJTSIMOOSA-N

description

Merck USA index - 14, 2538

assay

≥95% (HPLC)

form

crystalline powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

off-white, white to tan

solubility

ethanol: 50 mg/mL

shipped in

ambient

storage temp.

10-30°C

Quality Level

100

Biochem/physiol Actions

Cell permeable: no
Primary Target
Mineralocorticoid and glucocorticoid receptors
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Carcinogenic / Teratogenic (D)

General description

Corticosteroid hormone synthesized in response to stress. Binds to and activates mineralocorticoid and glucocorticoid receptors, resulting in altered genomic expression. Steroid-induced changes in protein synthesis eventually affect ionic conductances through the membrane. Also induces apoptosis in murine bone marrow.

Other Notes

Garvy, B.A., et al. 1993. Immunology80, 587.
DeKloet, E.R. 1992. Ann. N.Y. Acad. Sci.663, 357.
Joels, M., and deKloet, E.R. 1992. Trends Neurosci.15, 25.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

235135-1GM: + 235135-0GM: + 235135-GM: + 235135-1.1ML:

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Certificates of Analysis (COA)

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Global Trade Item Number

SKUGTIN
235135-1GMCN04055977199642

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