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Merck

361556

GSK-3 Inhibitor IX, Control, MeBIO

The GSK-3 Inhibitor IX, Control, MeBIO, also referenced under CAS 710323-61-8, controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

GSK-3 Inhibitor IX, Control, MeBIO, 1-Methyl-BIO

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About This Item

Empirical Formula (Hill Notation):
C17H12BrN3O2
CAS Number:
710323-61-8
Molecular Weight:
370.20
MDL number:
MFCD09037537
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Product Name

GSK-3 Inhibitor IX, Control, MeBIO, The GSK-3 Inhibitor IX, Control, MeBIO, also referenced under CAS 710323-61-8, controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

form

solid

InChI key

ATNXSIPNXWSMRK-PEZBUJJGSA-N

InChI

1S/C17H12BrN3O2/c1-21-13-8-9(18)6-7-11(13)14(17(21)22)16-15(20-23)10-4-2-3-5-12(10)19-16/h2-8,15,19H,1H3/b16-14-

SMILES string

Brc1cc2c(cc1)\C(=C3\Nc4c(cccc4)C\3N=O)\C(=O)N2C

assay

≥97% (HPLC)

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

dark red

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Relevant kinase inactive control
Product does not compete with ATP.
Reversible: no
Target IC50: >92 µM for Cdk1/B, >100 µM for Cdk5/p25, and GSK-3α/β

Disclaimer

Toxicity: Standard Handling (A)

General description

A cell-permeable N-methylated analog of GSK-3 Inhibitor IX, BIO (Cat. No. 361550) that serves as a relevant kinase inactive control (IC50 >92 µM for Cdk1/B, >100 µM for Cdk5/p25, and GSK-3α/β). Acts as a potent ligand for aryl hydrocarbon receptor (AhR; EC50 = 20 nM and 93 nM for yeast and hepatoma reporter systems, respectively) and displays antiproliferative properties.

Packaging

Packaged under inert gas

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Verónica Uribe-Etxebarria et al.
Cells, 9(3) (2020-03-12)
Dental pulp stem cells (DPSCs) from adult teeth show the expression of a very complete repertoire of stem pluripotency core factors and a high plasticity for cell reprogramming. Canonical Wnt and Notch signaling pathways regulate stemness and the expression of

Global Trade Item Number

SKUGTIN
361556-1MGCN04055977214161

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