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4995

Ouabain octahydrate

≥95% (HPLC), solid, Na⁺,K⁺-ATPase inhibitor, Calbiochem®

Synonym(s):

Ouabain, Octahydrate, Strophanthin G

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About This Item

Empirical Formula (Hill Notation):
C29H44O12 · 8H2O
CAS Number:
11018-89-6
Molecular Weight:
728.77
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00149240
Assay:
≥95% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light
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Product Name

Ouabain, Octahydrate, Inhibits Na+,K+-ATPase.

Quality Level

100

description

RTECS - RN3850000
Merck USA index - 14 6901

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white to off-white

solubility

hot water: 10 mg/mL, room-temperature water: insoluble

shipped in

ambient

storage temp.

2-8°C

SMILES string

O1CC(=CC1=O)[C@@H]2C3(C(C4[C@H]([C@@H](C3)O)C5([C@@H](C[C@@H](CC5(CC4)O)OC6OC(C(C(C6O)O)O)C)O)CO)(CC2)O)C.O.O.O.O.O.O.O.O

InChI

1S/C29H44O12.8H2O/c1-13-22(34)23(35)24(36)25(40-13)41-15-8-19(32)28(12-30)21-17(3-5-27(28,37)9-15)29(38)6-4-16(14-7-20(33)39-11-14)26(29,2)10-18(21)31;;;;;;;;/h7,13,15-19,21-25,30-32,34-38H,3-6,8-12H2,1-2H3;8*1H2/t13?,15-,16+,17?,18+,19+,21+,22?,23?,24?,25?,26?,27?,28?,29?;;;;;;;;/m0......../s1

InChI key

TYBARJRCFHUHSN-HMNHGHQSSA-N

General description

Inhibits Na+ and K+-dependent ATPases. Has cardiotonic properties.
Inhibits Na+,K+-ATPase. Exhibits cardiotonic properties. Preferentially enhances radiotoxicity in tumor cells and induces apoptosis by prolonging the irradiation-induced G2 delay.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Na+,K+-ATPase
Product does not compete with ATP.
Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 2 weeks at 4°C or for up to 2 months at -20°C.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Verheye-Dua, F.A., and Bohm, L. 2000. Strahlenther Onkol. 176, 186.
Hasenauer, J., et al. 1993. J. Biol. Chem.268, 3289.
Rakowski, F.F. 1993. J. Gen. Physiol.101, 117.
Mahaney, J.E., and Grisham, C.M. 1992. Biochemistry31, 2025.
Xu, Z.J., et al. 1992. J. Physiol.456, 405.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic (F)

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pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 1 Oral - Acute Tox. 3 Inhalation - STOT RE 2

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

4995-1GM: + 4995-1.1ML: + 4995-GM:

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Certificates of Analysis (COA)

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Global Trade Item Number

SKUGTIN
4995-1GMCN04055977199253