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Merck

517301

P-Glycoprotein Inhibitor, C-4

The P-Glycoprotein Inhibitor, C-4 controls the biological activity of P-Glycoprotein. This small molecule/inhibitor is primarily used for Cancer applications.

Synonym(s):

P-Glycoprotein Inhibitor, C-4, (E)-4-Chloro-N-(3-(3-(4-hydroxy-3-methoxyphenyl)acryloyl)phenyl)benzamide, C-4

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About This Item

Empirical Formula (Hill Notation):
C23H18ClNO4
CAS Number:
864426-22-2
Molecular Weight:
407.85
UNSPSC Code:
12352202
NACRES:
NA.77
PubChem Substance ID:
16062976

Key Documents

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InChI

1S/C23H18ClNO4/c1-29-22-13-15(6-12-21(22)27)5-11-20(26)17-3-2-4-19(14-17)25-23(28)16-7-9-18(24)10-8-16/h2-14,27H,1H3,(H,25,28)

InChI key

SFYVLZRWJCFMTJ-UHFFFAOYSA-N

SMILES string

COC1=C(C=CC(=C1)C=CC(=O)C2=CC(=CC=C2)NC(=O)C3=CC=C(C=C3)Cl)O

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: 10 mg/mL

shipped in

ambient

Quality Level

100

Related Categories

General description

A cell-permeable cinnamoyl compound that reversibly inhibits P-gp (P-glycoprotein) efflux function and reverses the MDR (multidrug resistance) phenotype with no noticeable effect on P-gp expression. Shown to significantly enhance Paclitaxel- (Cat. No. 580555) and Vincristine- (Cat. No. 677181) induced cytotoxicity as well as apoptosis in P-gp expressing KBV20C cells.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
P-Glycoprotein
Product does not compete with ATP.
Reversible: yes

Packaging

Packaged under inert gas

Other Notes

Kim, Y.K., et al. 2007. Biochem. Biophys. Res. Commun.355, 136.
Woo, H.B., et al. 2005. Bioorg. Med. Chem. Lett.15, 3782.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

517301-MG: + 517301-10MG:

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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Global Trade Item Number

SKUGTIN
517301-10MGCN04055977271874

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