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Merck

616464

SB 431542 hydrate

≥97% (HPLC), liquid, TGF-β RI kinase inhibitor, Calbiochem®

Synonym(s):

InSolution TGF-β RI Kinase Inhibitor VI, SB431542

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About This Item

Empirical Formula (Hill Notation):
C22H16N4O3 · 2H2O
CAS Number:
301836-41-9
Molecular Weight:
420.42
MDL number:
MFCD27976360
UNSPSC Code:
51111800
NACRES:
NA.77

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Product Name

TGF-β RI Kinase Inhibitor VI, SB431542, InSolution, ≥97%

SMILES string

[nH]1c(nc(c1c4cc5c(cc4)OCO5)c3ncccc3)c2ccc(cc2)C(=O)N

InChI

1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)

InChI key

FHYUGAJXYORMHI-UHFFFAOYSA-N

assay

≥97% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Related Categories

General description

A cell-permeable triarylimidazole compound that is shown to effectively inhibit cellular Smad2 phosphorylation (>90% inhibition by 10 µM inhibitor) upon vector-mediated expression of constitutively active ALK4, ALK5, or ALK7 in NIH 3T3 cells, while exhibiting little effect against Smad1 phosphorylation by other members of type I receptors for TGF-β in NIH 3T3 cultures expressing active ALK1, 2, 3, or 6. When tested directly in cell-free kinase assays, SB431542 is demonstrated to potently inhibit the activity of ALK4 and ALK5 (IC50 = 140 nM and 94 nM, respectively) with no or much reduced potency toward a panel of 24 other kinases (IC50 ≥10 µM in the presence of 10 µM ATP), including ALK2 and ALK6. Reported to improve the efficiency of 4-TF-induced human iPSCs generation from fibroblast cultures by >200-fold when used together with PD0325901 (Cat. No. 444966) and Thiazovivin (Cat. No. 420220).

Packaging

Packaged under inert gas

Physical form

A 100 mM (5 mg/119 µl) solution of SB431542 (Cat. No. 616461) in DMSO.

Preparation Note

Following initial thaw, aliquot and freeze (-20°C).

Other Notes

Ikushima, H., et al. 2009. Cell Stem Cell5, 504.
Lin, T., et al. 2009. Nat. Methods6, 805.
Maherali, N. and Hochedlinger, K., 2009. Curr. Biol.19, 1718.
Callahan, J.F., et al. 2002. J. Med. Chem.45, 999.
Inman, G.J., et al. 2002. Mol. Pharmacol.62, 65.
Laping, N.J., et al. 2002. Mol. Pharmacol.62, 58.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

188.6 °F - (refers to pure substance)

flash_point_c

87 °C - (refers to pure substance)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Group 4: Flammable liquids + Type 3 petroleums + Hazardous rank III + Water insoluble liquid

fsl

616464-5MG:

jan

Certificates of Analysis (COA)

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Global Trade Item Number

SKUGTIN
616464-5MGCN04055977185942

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