AB3314P
Anti-Monocarboxylate Transporter 4 Antibody
Chemicon®, from rabbit
Synonym(s):
MCT4
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, WB
Citations:
25
biological source
rabbit
conjugate
unconjugated
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
rat
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SLC16A3(9123)
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Immunogen
A 19 amino acid peptide sequence near the C-terminus of rat/human/mouse MCT4.
Application
Detect Monocarboxylate Transporter 4 using this Anti-Monocarboxylate Transporter 4 Antibody validated for use in ELISA & WB.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Ion Channels & Transporters
Ion Channels & Transporters
Western blot: 1-5 mg/mL using ECL.
ELISA: 1:10,000-1:100,000 using 50-100 ng control peptide per well.
Optimal working dilutions must be determined by the end user.
ELISA: 1:10,000-1:100,000 using 50-100 ng control peptide per well.
Optimal working dilutions must be determined by the end user.
Biochem/physiol Actions
Recognizes rat Monocarboxylate Transporter 4 (MCT4/MOT4/ SLC16A3). The immunogen shows no significant sequence homology with other MCT. MCT4 is prominently expressed in skeletal muscle and other cells with high glycolytic rate such as tumors cells and white blood cells suggesting an important role in lactic acid efflux.
Note: According to new nomenclature, the old MCT3 has now been reclassified as MCT4. Consult Halestrap and Price (1999) Biochem. J. 343:281-299.
SPECIES REACTIVITIES:
Rat. The immunogen sequence is 100% conserved in human and mouse and 78% conserved in chicken. Reactivity with other species has not been confirmed.
Note: According to new nomenclature, the old MCT3 has now been reclassified as MCT4. Consult Halestrap and Price (1999) Biochem. J. 343:281-299.
SPECIES REACTIVITIES:
Rat. The immunogen sequence is 100% conserved in human and mouse and 78% conserved in chicken. Reactivity with other species has not been confirmed.
Physical form
Affinity purified immunoglobulin. Liquid in PBS containing 0.1% BSA and 0.05% sodium azide.
Preparation Note
Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Replaces: AB3546P
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Listings
Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.
AB3314P:
jan
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Cellular expression of monocarboxylate transporters in the female reproductive organ of mice: implications for the genital lactate shuttle.
Kuchiiwa T, Nio-Kobayashi J, Takahashi-Iwanaga H, Yajima T, Iwanaga T
Histochemistry and Cell Biology null
Jieyun Cao et al.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 20(1), 435-444 (2017-12-19)
Monocarboxylate transporters (MCTs) are involved in the transport of monocarboxylates such as ketone bodies, lactate, and pharmaceutical agents. CD147 functions as an ancillary protein for MCT1 and MCT4 for plasma membrane trafficking. Sex differences in MCT1 and MCT4 have been
A Nagai et al.
Placenta, 31(2), 126-133 (2009-12-22)
Lactate plays an important role as an alternative energy substrate, especially in conditions with a decreased utility of glucose. Proton-coupled monocarboxylate transporters (MCTs) are essential for the transport of lactate, ketone bodies, and other monocarboxylates through the plasma membrane and
Masataka Suwa et al.
Clinical and experimental pharmacology & physiology, 32(3), 218-223 (2005-03-04)
1. The present study was designed to examine the role of calcineurin in muscle metabolic components by the administration of the specific calcineurin inhibitor cyclosporine A (CsA) to rats. 2. Male Wistar rats were divided into either a CsA-treated group
Claire Thomas et al.
American journal of physiology. Endocrinology and metabolism, 293(4), E916-E922 (2007-07-05)
This study investigated the effects of high-intensity training, with or without induced metabolic alkalosis, on lactate transporter (MCT1 and MCT4) and sodium bicarbonate cotransporter (NBC) content in rat skeletal muscles. Male Wistar rats performed high-intensity training on a treadmill 5
Related Content
Global Trade Item Number
| SKU | GTIN |
|---|---|
| AB3314P | 04053252586149 |
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