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Merck

AB9904

Anti-QKI-5 Antibody

serum, Chemicon®

Synonym(s):

Quaking Protein

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunoprecipitation (IP)
western blot
Species reactivity:
mouse, human, rat
Citations:
7
Technique(s):
immunoprecipitation (IP): suitable
western blot: suitable
Uniprot accession no.:
Q96PU8

Key Documents

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Product Name

Anti-QKI-5 Antibody, serum, Chemicon®

biological source

rabbit

conjugate

unconjugated

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse, human, rat

manufacturer/tradename

Chemicon®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

NCBI accession no.

NM_006775.1
NM_206853.1
NM_206854.1
NM_206855.1

UniProt accession no.

Q96PU8

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... QKI(9444)

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Analysis Note

Control
Positive Control: Glial cells, astrocytes and oligodendrocytes.

Application

Detect QKI-5 using this Anti-QKI-5 Antibody validated for use in IP & WB.
Research Category
Neuroscience
Research Sub Category
Developmental Neuroscience

RNA Binding Protein (RBP)

Biochem/physiol Actions

QKI-5 (Quaking Protein). The antibody recognizes the ~40 kDa protein.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

QKI is an RNA-binding protein that plays a central role in myelinization. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. It is regulated by alternative splicing.
~40 kDa

Immunogen

Synthetic peptide from mouse QKI-5.

Physical form

Liquid.
Serum

Preparation Note

Maintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.

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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

AB9904:

jan

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Fang Wang et al.
Cell research, 27(3), 416-439 (2017-03-01)
MicroRNA (miRNA) biogenesis is finely controlled by complex layers of post-transcriptional regulators, including RNA-binding proteins (RBPs). Here, we show that an RBP, QKI5, activates the processing of primary miR-124-1 (pri-124-1) during erythropoiesis. QKI5 recognizes a distal QKI response element and
Xingyu Yang et al.
Journal of cellular and molecular medicine, 25(12), 5655-5670 (2021-05-05)
Preeclampsia (PE) is characterized by placental ischemia and hypoxia, resulting in abnormal casting of the uterine spiral artery, which is mainly caused by insufficient trophoblastic cell infiltration. A reduction in levels of growth factor-based signalling via Neuropilin-1 (NRP1) has been
R J Hardy et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 16(24), 7941-7949 (1996-12-15)
qkI, a newly cloned gene lying immediately proximal to the deletion in the quakingviable mutation, is transcribed into three messages of 5, 6, and 7 kb. Antibodies raised to the unique carboxy peptides of the resulting QKI proteins reveal that
Benjamin Rauwel et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 35(4), 753-765 (2019-12-14)
Increased osteoclastogenesis is a common feature of bone erosion, notably in osteoporosis but also in inflammatory diseases such as rheumatoid arthritis (RA) and osteoarticular infections. Human cytomegalovirus (HCMV) infection has been described to impair monocyte differentiation into macrophages and dendritic
Kai Li et al.
Cell death & disease, 10(10), 699-699 (2019-09-22)
Spermatogenesis is the complex process of male germline development and requires coordinated interactions by multiple gene products that undergo strict developmental regulations. Increasing evidence has suggested that a number of long noncoding RNAs (lncRNAs) may function as important regulatory molecules
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Related Content

RNA-Binding Protein Immunoprecipitation

All eukaryotic organisms require tight regulation of gene expression for complex processes such as development, differentiation, cell specification, and responses to environmental stimuli. Many genes are regulated post-transcriptionally, in addition to transcriptional mechanisms of gene regulation. RNA-binding proteins (RBPs) are essential for post-transcriptional gene regulation, linking transcription and translation in many processes including transcription, splicing, export, rate of translation and turnover. In all of these events, RBPs coordinate regulation of the amount of protein produced from mRNA transcripts.

RABBIT ANTI-QKI-5

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