Skip to Content
Merck

ABN1385

Anti-RanBP2 Antibody

from rabbit, purified by affinity chromatography

Synonym(s):

E3 SUMO-protein ligase RanBP2, 358 kDa nucleoporin, Nuclear pore complex protein Nup358, Nucleoporin Nup358, Ran-binding protein 2, RanBP2, p270, ADANE, ANE1, IIAE3, Transformation-Related Protein 2, TRP1, TRP2

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
polyclonal
Species reactivity:
human, mouse
Application:
IF, IHC
Technique(s):
immunofluorescence: suitable, immunohistochemistry: suitable
Citations:
5
Uniprot accession no.:
P49792

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

biological source

rabbit

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human, mouse

technique(s)

immunofluorescence: suitable, immunohistochemistry: suitable

NCBI accession no.

NP_006258

UniProt accession no.

P49792

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... RANBP2(5903)

Analysis Note

Evaluated by Immunohistochemistry in human retina tissue.

Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected RanBP2 in human retina tissue.

Application

Anti-RanBP2 Antibody is an antibody against RanBP2 Antibody for use in Immunohistochemistry, Immunofluorescence.
Immunofluorescence Analysis: A 1:50 dilution from a representative lot detected RanBP2 in mouse retina cells (Paulo Ferreira, Duke University)
Immunofluorescence Analysis: A representative lot detected in mouse retina of RanBP2 transgenic mice (Cho, K., et al. (2014). JBC. 1-31).
Research Category
Neuroscience
Research Sub Category
Developmental Signaling

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

358.2 kDa calculated
RAN-binding protein 2 (RanBP2), also known as Nucleoporin Nup358 (Nup358), is encoded by the RANBP2 gene. RanBP2/Nup358 regulates functions of multiple cellular proteins through direct interactions via distinct domains. RanBP2/Nup358 binding partners include Ran GTPase, importin-beta, exportin-1/CRM1, red opsin, subunits of the proteasome, cox11, the kinesin-1 isoforms KIF5B and KIF5C, and E2 enzyme UBC9, where it functions as an E3 SUMO-protein ligase and facilitates subsequent SUMOylation of protein substrates such as RanGAP and SP100.

Immunogen

Epitope: Internal repeat IR1+2 domain (IR)
Recombinant protein corresponding to the internal repeat IR1+2 domain (IR) of human RanBP2.

Other Notes

Concentration: Please refer to lot specific datasheet.

Physical form

Affinity purified
Purified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

Not finding the right product?  

Try our Product Selector Tool.

Storage Class

10 - Combustible liquids

wgk

WGK 2

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

ABN1385:

jan

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Jeeyoung Lee et al.
Cells, 10(9) (2021-09-29)
Cellular stress induces the formation of membraneless protein condensates in both the nucleus and cytoplasm. The nucleocytoplasmic transport of proteins mainly occurs through nuclear pore complexes (NPCs), whose efficiency is affected by various stress conditions. Here, we report that hyperosmotic
Kyoung-in Cho et al.
The Journal of biological chemistry, 289(8), 4600-4625 (2014-01-10)
The immunophilins, cyclophilins, catalyze peptidyl cis-trans prolyl-isomerization (PPIase), a rate-limiting step in protein folding and a conformational switch in protein function. Cyclophilins are also chaperones. Noncatalytic mutations affecting the only cyclophilins with known but distinct physiological substrates, the Drosophila NinaA
Samuel S Pappas et al.
Human molecular genetics, 27(3), 407-420 (2017-12-01)
A critical challenge to deciphering the pathophysiology of neurodevelopmental disease is identifying which of the myriad abnormalities that emerge during CNS maturation persist to contribute to long-term brain dysfunction. Childhood-onset dystonia caused by a loss-of-function mutation in the AAA+ protein torsinA
Baojin Ding et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(9), 2024-2038 (2021-01-21)
DYT1 dystonia is a hereditary neurologic movement disorder characterized by uncontrollable muscle contractions. It is caused by a heterozygous mutation in Torsin A (TOR1A), a gene encoding a membrane-embedded ATPase. While animal models provide insights into disease mechanisms, significant species-dependent

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service