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Merck

HAGP1MAG-12K

MILLIPLEX® Human Angiogenesis/Growth Factor Magnetic Bead Panel - Cancer Multiplex Assay

Angiogenesie Bead-Based Multiplex Assays using the Luminex technology enables the simultaneous analysis of multiple angiogenic biomarkers in human serum, plasma and cell culture samples.

Synonym(s):

human oncology growth factor immunoassay panel, luminex human cancer angiogenesis growth factor multiplex assay, millipore human cancer growth factor protein multiplex kit

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About This Item

UNSPSC Code:
12161503
eCl@ss:
32161000
NACRES:
NA.84

Key Documents

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Quality Level

200

species reactivity

human

manufacturer/tradename

Milliplex®

assay range

accuracy: 42-131%
standard curve range: 1.4-1,000 pg/mL
(HB-EGF, IL-8, PLGF)
standard curve range: 13.7-10,000 pg/mL
(Angiopoietin-2, FGF-1, FGF-2, G-CSF, VEGF-A)
standard curve range: 137.2-100,000 pg/mL
(Leptin)
standard curve range: 2.7-2,000 pg/mL
(BMP-9, EGF, Endothelin-1)
standard curve range: 27.4-20,000 pg/mL
(Endoglin, Follistatin, HGF)
standard curve range: 6.9-5,000 pg/mL
(VEGF-C, VEGF-D)

technique(s)

multiplexing: suitable

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

Related Categories

General description

Angiogenesis, the development of new vascular networks, is a key process in normal growth and development as well as in wound healing, with homeostasis maintained by a delicate balance of angiogenic factors and inhibitors. Consequently, insufficient, or excessive blood vessel growth underlies many diseases, including cardiovascular disease, diabetic ulcers, macular degeneration, and cancer. Angiogenesis plays a significant role in tumor growth and metastasis.

The MILLIPLEX® Human Angiogenesis / Growth Factor Panel 1 is to be used for the simultaneous quantification of any or all of the following 17 human angiogenesis and growth factor biomarkers in human plasma, serum samples and tissue/cell lysate and culture supernatant samples: Angiopoietin-2, BMP-9, EGF, Endoglin, Endothelin-1, FGF-1 (acidic FGF), FGF-2 (basic FGF), Follistatin, G-CSF, HB-EGF, HGF, IL-8, Leptin, PLGF, VEGF-A, VEGF-C and VEGF-D. This kit uses a 96-well format, contains a lyophilized standard cocktail, two internal assay quality controls and can measure up to 38 samples in duplicate.

The Luminex® xMAP® platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.

Panel Type: Circulating Cancer

Application

  • Analytes: Angiopoietin-2, BMP-9, EGF, Endoglin, Endothelin-1, FGF-1 (acidic FGF), FGF-2 (basic FGF), Follistatin, G-CSF, HB-EGF, HGF, IL-8, Leptin, PLGF, VEGF-A, VEGF-C, VEGF-D
  • Recommended Sample Type: Human serum, plasma, tissue/cell lysate or culture supernatants
  • Recommended Sample Dilution: 25 μL per well of a 1:3 dilution of plasma or serum; 25 μL cell culture supernatant per well, diluted with appropriate control medium as needed
  • Assay Run Time: Overnight (16-18 hours) at 2-8°C
  • Research Category: Cancer

Biochem/physiol Actions

Cross Reactivty
Cross-reactivity between the antibodies and any of the other analytes in this panel is non-detectable or negligible.

Features and Benefits

Design your multiplex kit by choosing available analytes within this panel.

Packaging

Everything you need in a single kit.

Preparation Note

Recommended storage for kit components is 2 - 8°C.

Other Notes

Sensitivity: Refer to kit protocol for sensitivities of individual analytes.

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

Target Organs

Respiratory Tract

Storage Class Code

10 - Combustible liquids

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PDSCL

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PRTR

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FSL

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ISHL Indicated Name

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ISHL Notified Names

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Cartagena Act

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JAN Code

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Certificates of Analysis (COA)

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Christopher A Adase et al.
The Journal of biological chemistry, 291(22), 11635-11646 (2016-04-07)
A critical function for skin is that when damaged it must simultaneously identify the nature of the injury, repair barrier function, and limit the intrusion of pathogenic organisms. These needs are carried out through the detection of damage-associated molecular patterns
Neil Patel et al.
American journal of physiology. Lung cellular and molecular physiology, 308(4), L378-L383 (2014-12-07)
Pulmonary hypertension (PH) due to abnormal pulmonary vascular development is an important determinant of illness severity in congenital diaphragmatic hernia (CDH). Vascular endothelial growth factor A (VEGFA) and placental growth factor (PLGF) may be important mediators of pulmonary vascular development
Ruijin Shao et al.
Data in brief, 6, 135-142 (2016-02-10)
In this data, non-pregnant women during the menstrual cycle, women with normal intrauterine pregnancy (IUP), and women with tubal ectopic pregnancy (EP) after informed consent were included. The serum levels of 17β-estradiol, progesterone, testosterone, beta-human chorionic gonadotropin, interleukin (IL)-1β, IL-4
Qing Xu et al.
Journal of diabetes research, 2022, 8435603-8435603 (2022-02-01)
To investigate the aqueous levels of angiogenic factors in nonproliferative diabetic retinopathy (NPDR) patients with diabetic macular edema (DME) and to ascertain their association with optical coherence tomography angiography (OCTA) metrics. This study enrolled 21 NPDR eyes with DME (NPDR/DME+)
Kevin P Daly et al.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 32(1), 120-128 (2012-12-25)
Cardiac allograft vasculopathy (CAV), the major cause of late allograft loss after cardiac transplantation, results from donor-directed cellular and humoral alloimmune responses. Graft vascular endothelial cells (EC) are primary targets of these destructive responses, suggesting that factors associated with endothelial
View All Related Papers

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