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26454

Magnesium stearate

Name: Magnesium stearate
Brand: SIAL

puriss., meets analytical specification of Ph. Eur., BP, ≥90% stearic and palmitic acid basis, ≥40% stearic acid basis (GC), 4.0-5.0% Mg basis (calc on dry sub.)

Synonym(s):

Stearic acid magnesium salt

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About This Item

Linear Formula:

[CH₃(CH₂)₁₆CO₂]₂Mg

CAS Number:

557-04-0

Molecular Weight:

591.24

UNSPSC Code:

12352106

NACRES:

NA.22

PubChem Substance ID:

57648176

EC Number:

209-150-3

Beilstein/REAXYS Number:

3919702

MDL number:

MFCD00036391

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Properties

grade

puriss.

assay

≥40% stearic acid basis (GC), ≥90% stearic and palmitic acid basis, 4.0-5.0% Mg basis (calc on dry sub.)

quality

meets analytical specification of Ph. Eur., BP

impurities

acidity or alkalinity, complies, microbiological impurity, in accordance, residual solvents, complies

loss

≤6.0% loss on drying, 105 °C

mp

200 °C (lit.)

acid value

195‑210(fatty acid)

solubility

alcohol: insoluble, diethyl ether: insoluble, water: insoluble

anion traces

chloride (Cl^-): ≤1000 mg/kg, sulfate (SO₄^2-): ≤5000 mg/kg

cation traces

Cd: ≤3 mg/kg, Ni: ≤5 mg/kg, Pb: ≤10 mg/kg

suitability

in accordance for fatty acid composition, passes test for identity

application(s)

pharmaceutical (small molecule)

SMILES string

CCCCCCCCCCCCCCCCCC(=O)O[Mg]OC(=O)CCCCCCCCCCCCCCCCC

InChI

1S/2C18H36O2.Mg/c2*1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;/h2*2-17H2,1H3,(H,19,20);/q;;+2/p-2

InChI key

HQKMJHAJHXVSDF-UHFFFAOYSA-L

Description

Application

Magnesium stearate has been used as a tablet and capsule lubricant. It has also been used for preparing microcapsules.

Biochem/physiol Actions

Magnesium stearate is the magnesium salt of stearic acid that possess lubricating properties and hence prevents ingredients from sticking to manufacturing equipment during the compression of chemical powders into solid tablets. Dry coating of drugs with magnesium stearate leads to flow improvement, flow-aid and lubrication effects, tabletability as well as non-inhibited dissolution rate.

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Storage Class

11 - Combustible Solids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

26454-1KG:4.54817325278E12 + 26454-20KG:4.548173252797E12 + 26454-25KG:4.548173252803E12 + 26454-6X1KG:4.54817325281E12

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