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Merck

69479

N-Methyl-N-(trimethylsilyl)trifluoroacetamide

derivatization grade (GC derivatization), LiChropur™, ≥98.5%

Synonym(s):

N-Trimethylsilyl-N-methyl trifluoroacetamide, MSTFA

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About This Item

Linear Formula:
CF3CON(CH3)Si(CH3)3
CAS Number:
24589-78-4
Molecular Weight:
199.25
UNSPSC Code:
23151817
NACRES:
NA.22
PubChem Substance ID:
329761689
EC Number:
246-331-6
Beilstein/REAXYS Number:
1941550
MDL number:
MFCD00000411

Key Documents

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Product Name

N-Methyl-N-(trimethylsilyl)trifluoroacetamide, derivatization grade (GC derivatization), LiChropur™, ≥98.5%

InChI key

MSPCIZMDDUQPGJ-UHFFFAOYSA-N

InChI

1S/C6H12F3NOSi/c1-10(12(2,3)4)5(11)6(7,8)9/h1-4H3

SMILES string

CN(C(=O)C(F)(F)F)[Si](C)(C)C

grade

derivatization grade (GC derivatization)

vapor density

>1 (vs air)

vapor pressure

8.8 mmHg ( 27 °C)

assay

≥98.5% (GC)
≥98.5%

form

liquid

quality

LiChropur™

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

technique(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.38 (lit.)
n20/D 1.380

bp

130-132 °C (lit.)

density

1.075 g/mL at 25 °C (lit.)

storage temp.

2-8°C

Quality Level

200

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Application

Learn more in the Product Information
MSTFA may be used in silylation procedure to detemine steroid hormones 17α-ethinylestradiol (EE2) and estrone using GC-MS. MSTFA along with Trimethylsilyl chloride (TMCS) in eithyl acetate, acetonitrile and dichloromethane solvents leads to formation of trimethylsilyl (TMS) and tert-butyldimethylsilyl (TBS) derivatives.
Suitable for the derivatization of amines, amino acids, carboxyl, hydroxyamines, indolalkylamine, n-nitrosoamino acids, nucleosides, phenolalkylamines, serotonin and tryptamine.

General description

N-Methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA) is a silylating reagent.

Other Notes

Powerful silylating agent
Reagent for N-acetyl-N, trifluoroacetyl, trimethylsilyl, N-trimethylsilyl-N-trifluoroacetyl, and O-trimethylsilyl (TMS)

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

77.0 °F - closed cup

flash_point_c

25 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
BCCH1152
BCCF4495
BCCC1892
BCCC2821
BCCB9289

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J. Heberle et al.
Silylating Agents, 2nd ed. (1995)
Journal of Chromatography A, 115, 591-591 (1975)
M. Donike
Chromatographia, 9, 440-440 (1976)
M Donike et al.
Journal of chromatography, 134(2), 385-395 (1977-04-11)
The 1N-TMS-omegan-TFA-derivatives of indolalkylamines are suitable for estimation by combined gas chromatography and mass spectrometry for two reasons, viz. (1) Under electron impact charge stabilisation at the indole nucleus is favoured, so structure-specific ions form the base peak. For unsubstituted
Hieng-Ming Ting et al.
Frontiers in plant science, 11, 257-257 (2020-03-27)
Glucosinolates are defense-related secondary metabolites found in Brassicaceae. When Brassicaceae come under attack, glucosinolates are hydrolyzed into different forms of glucosinolate hydrolysis products (GHPs). Among the GHPs, isothiocyanates are the most comprehensively characterized defensive compounds, whereas the functional study of
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Articles

Silylation of Non-Steroidal Anti-Inflammatory Drugs

Results of a study involving the ability few Fluka silylating reagents to form GC-MS-compatible trimethylsilylmethyl derivatives of NSAIDs

Fatty Acid Methyl Ester analysis by Gas Chromatography

Development and validation of a fatty acid methyl esterification method, using methanolic HCl reagent, for FAME analysis by GC of vegetable oils and fats.

Protocols

MSTFA/MSTFA-d9 Derivatization of Amphetamine for GC/MS Detection and Identification

Example displays how MSTFA/MSTFA-d9 derivatization of amphetamine provides valuable information in mass spectra and chromatograms using SLB-5ms GC column.

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