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Merck

C0430

(−)-Cotinine solution

drug standard, 1.0 mg/mL in methanol

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About This Item

NACRES:
NA.24
PubChem Substance ID:
329774789
UNSPSC Code:
41116107
EC Number:
200-659-6
MDL number:
MFCD00077696

Key Documents

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grade

drug standard

Quality Level

100

agency

EPA 1694

concentration

1.0 mg/mL in methanol

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

environmental
pharmaceutical (small molecule)

format

single component solution

storage temp.

2-8°C

SMILES string

CN1[C@@H](CCC1=O)c2cccnc2

InChI

1S/C10H12N2O/c1-12-9(4-5-10(12)13)8-3-2-6-11-7-8/h2-3,6-7,9H,4-5H2,1H3/t9-/m0/s1

InChI key

UIKROCXWUNQSPJ-VIFPVBQESA-N

Gene Information

human ... CYP1A2(1544), CYP2A6(1548)
mouse ... Cyp2a5(13087)

Related Categories

General description

(−)-Cotinine is a major metabolite of nicotine, widely used as a biochemical marker for to evaluate the exposure to environmental tobacco smoke, for the validation of abstinence smoking and to determine the percentage of active smoking behavior.

Application

(−)-Cotinine solution has been used as a standard in the analysis of nicotine in air samples using ultra performance liquid chromatography-mass spectrometry (UPLC-MS).
(−)-Cotinine solution has been used as a standard in the analysis of nicotine in air samples using ultra performance liquid chromatography-mass spectrometry (UPLC-MS). (−)-Cotinine may be may used as an analytical reference standard for the quantification of the analyte in biological samples using high-performance liquid chromatography technique.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

51.8 °F - closed cup

flash_point_c

11 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Group 4: Flammable liquids + Alcohols + Hazardous rank II

fsl

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

C0430-VAR: + C0430-1ML:4548173190105 + C0430-BULK:

jan

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Certificates of Analysis (COA)

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A simple, sensitive, and rapid method for the determination of cotinine in urine by high-performance liquid chromatography with UV detection
Rabbaa-Khabbaz L, et al.
Journal of Chromatographic Science, 44(9), 535-538 (2006)
A sensitive HPLC-ESI-MS-MS method for the determination of cotinine in urine
Apinan R, et al.
Journal of Chromatographic Science, 48(6), 460-465 (2010)
Mohammad A Kaisar et al.
BMC neuroscience, 18(1), 71-71 (2017-10-13)
A sensitive, rapid and selective UHPLC-MS/MS method has been developed and validated for the quantification of Nicotine (NT) and Cotinine (CN) using Continine-d A linear response function was established for the range of concentrations 3-200 (r > 0.995) for NT and 3-600 ng/mL
Rapid and sensitive high-performance liquid chromatographic determination of nicotine and cotinine in nonsmoker human and rat urines
Oddoze.C, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 708(1-2), 95-101 (1998)
Assessment of nicotine for second hand smoke exposure in some public places in Romania by UPLC-MS
Bratan A, et al.
Chemistry Central Journal, 8(1), 29-29 (2014)
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